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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1992 Volume 1 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1992 Volume 1 Issue 1

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Article

GROWTH-INHIBITION OF HT29 CELLS EXPOSED TO N-METHYLFORMAMIDE CORRELATES WITH ALTERED EXPRESSION OF ALPHA-6/BETA-4 INTEGRIN

  • Authors:
    • D DEL BUFALO
    • G ZUPI
    • I D' AGNANO
    • R FALCIONI
    • M MARANGOLO
    • A SACCHI

  • View Affiliations / Copyright

    Affiliations: CRS IST REGINA ELENA STUDIO & CURA TUMORI,CHEMIOTERAPIA SPERIMENTALE PRECLIN,I-00158 ROME,ITALY. CRS IST REGINA ELENA STUDIO & CURA TUMORI,ONCOGENESI MOLEC LAB,I-00158 ROME,ITALY. OSPED RAVENNA,DIV ONCOL MED,RAVENNA,ITALY.
  • Pages: 97-105
    |
    Published online on: June 1, 1992
       https://doi.org/10.3892/ijo.1.1.97
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Abstract

The anticancer agent N-methylformamide (NMF) suppresses the expression of the c-myc proto-oncogene in human colon carcinoma cells while increasing the doubling time and reducing tumorigenicity in these cells. However, the mechanism by which NMF exerts its effects has remained unclear. We compared the expression of c-myc and of other growth-regulated genes (p53, beta-actin) to that of the H3 histone gene, which is specifically expressed in S-phase cells, in HT29 human colon carcinoma cells maintained in vitro or in nude mice. The growth fraction of the cell populations in the presence or absence of NMF was also evaluated at different days of growth by flow cytometric analysis. To assess whether prolonged exposure to NMF might induce a different phenotype in human carcinoma cells, the expression of alpha6, beta1, and beta4 integrin subunits were evaluated. The data indicate that NMF treatment induces a reduction in the growth fraction of HT29 colon carcinoma cells accompanied by a reduction in c-myc, H3 histone, p53, and beta-actin gene expression, and that prolonged exposure to NMF induces elevated expresssion of alpha6/beta4 integrin receptor, These data suggest that NMF-induced reduction of the proliferative capacity supports a different 'maturation status' of colon carcinoma cells which is defined by an elevated expression of the alpha6/beta4 integrin.

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Copy and paste a formatted citation
Spandidos Publications style
DEL BUFALO D, ZUPI G, D' AGNANO I, FALCIONI R, MARANGOLO M and SACCHI A: GROWTH-INHIBITION OF HT29 CELLS EXPOSED TO N-METHYLFORMAMIDE CORRELATES WITH ALTERED EXPRESSION OF ALPHA-6/BETA-4 INTEGRIN. Int J Oncol 1: 97-105, 1992.
APA
DEL BUFALO, D., ZUPI, G., D' AGNANO, I., FALCIONI, R., MARANGOLO, M., & SACCHI, A. (1992). GROWTH-INHIBITION OF HT29 CELLS EXPOSED TO N-METHYLFORMAMIDE CORRELATES WITH ALTERED EXPRESSION OF ALPHA-6/BETA-4 INTEGRIN. International Journal of Oncology, 1, 97-105. https://doi.org/10.3892/ijo.1.1.97
MLA
DEL BUFALO, D., ZUPI, G., D' AGNANO, I., FALCIONI, R., MARANGOLO, M., SACCHI, A."GROWTH-INHIBITION OF HT29 CELLS EXPOSED TO N-METHYLFORMAMIDE CORRELATES WITH ALTERED EXPRESSION OF ALPHA-6/BETA-4 INTEGRIN". International Journal of Oncology 1.1 (1992): 97-105.
Chicago
DEL BUFALO, D., ZUPI, G., D' AGNANO, I., FALCIONI, R., MARANGOLO, M., SACCHI, A."GROWTH-INHIBITION OF HT29 CELLS EXPOSED TO N-METHYLFORMAMIDE CORRELATES WITH ALTERED EXPRESSION OF ALPHA-6/BETA-4 INTEGRIN". International Journal of Oncology 1, no. 1 (1992): 97-105. https://doi.org/10.3892/ijo.1.1.97
Copy and paste a formatted citation
x
Spandidos Publications style
DEL BUFALO D, ZUPI G, D' AGNANO I, FALCIONI R, MARANGOLO M and SACCHI A: GROWTH-INHIBITION OF HT29 CELLS EXPOSED TO N-METHYLFORMAMIDE CORRELATES WITH ALTERED EXPRESSION OF ALPHA-6/BETA-4 INTEGRIN. Int J Oncol 1: 97-105, 1992.
APA
DEL BUFALO, D., ZUPI, G., D' AGNANO, I., FALCIONI, R., MARANGOLO, M., & SACCHI, A. (1992). GROWTH-INHIBITION OF HT29 CELLS EXPOSED TO N-METHYLFORMAMIDE CORRELATES WITH ALTERED EXPRESSION OF ALPHA-6/BETA-4 INTEGRIN. International Journal of Oncology, 1, 97-105. https://doi.org/10.3892/ijo.1.1.97
MLA
DEL BUFALO, D., ZUPI, G., D' AGNANO, I., FALCIONI, R., MARANGOLO, M., SACCHI, A."GROWTH-INHIBITION OF HT29 CELLS EXPOSED TO N-METHYLFORMAMIDE CORRELATES WITH ALTERED EXPRESSION OF ALPHA-6/BETA-4 INTEGRIN". International Journal of Oncology 1.1 (1992): 97-105.
Chicago
DEL BUFALO, D., ZUPI, G., D' AGNANO, I., FALCIONI, R., MARANGOLO, M., SACCHI, A."GROWTH-INHIBITION OF HT29 CELLS EXPOSED TO N-METHYLFORMAMIDE CORRELATES WITH ALTERED EXPRESSION OF ALPHA-6/BETA-4 INTEGRIN". International Journal of Oncology 1, no. 1 (1992): 97-105. https://doi.org/10.3892/ijo.1.1.97
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