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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 1992 Volume 1 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1992 Volume 1 Issue 2

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Article

DIFFERENTIAL SPLICING OF THE NEUROFIBROMATOSIS TYPE-1 GENE IN THE RAT - SPLICE VARIANTS HOMOLOGOUS WITH THE HUMAN ARE EXPRESSED IN RAT-CELLS

  • Authors:
    • AP KYRITSIS
    • PSY LEE
    • H MOCHIZUKI
    • T NISHI
    • VA LEVIN
    • H SAYA

  • View Affiliations / Copyright

    Affiliations: UNIV TEXAS,MD ANDERSON CANC CTR,DEPT NEUROONCOL,BOX 100,1515 HOLCOMBE BLVD,HOUSTON,TX 77030.
  • Pages: 149-152
    |
    Published online on: July 1, 1992
       https://doi.org/10.3892/ijo.1.2.149
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Abstract

The GTPase activating protein-related domain (GRD) of the human neurofibromatosis type 1 gene (NF1) was shown to have two types of splice variants. Through polymerase chain reaction (PCR), we isolated and sequenced three types of splice variants in the rat NF1-GRD. Type I and II transcripts were highly homologous with the human transcripts. The type III NF1-GRD transcript, unidentified in the human, had an additional 41-bp insert immediately downstream from the 63-bp insert of the type II transcript. The type III transcript encoded for a protein that prematurely terminated its predicted amino acid sequence because of a stop codon, resulting in possible modification of the GAP activity. All three transcripts were found in the rat's liver, cerebral hemispheres, spinal cord, colon, and spleen, whereas the other organs examined had only type I and II transcripts. This differential splicing mechanism may regulate the activity or compartmentalization of the NF1 protein, resulting in modulation of the Ras-related signal transduction pathway.

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Copy and paste a formatted citation
Spandidos Publications style
KYRITSIS A, LEE P, MOCHIZUKI H, NISHI T, LEVIN V and SAYA H: DIFFERENTIAL SPLICING OF THE NEUROFIBROMATOSIS TYPE-1 GENE IN THE RAT - SPLICE VARIANTS HOMOLOGOUS WITH THE HUMAN ARE EXPRESSED IN RAT-CELLS. Int J Oncol 1: 149-152, 1992.
APA
KYRITSIS, A., LEE, P., MOCHIZUKI, H., NISHI, T., LEVIN, V., & SAYA, H. (1992). DIFFERENTIAL SPLICING OF THE NEUROFIBROMATOSIS TYPE-1 GENE IN THE RAT - SPLICE VARIANTS HOMOLOGOUS WITH THE HUMAN ARE EXPRESSED IN RAT-CELLS. International Journal of Oncology, 1, 149-152. https://doi.org/10.3892/ijo.1.2.149
MLA
KYRITSIS, A., LEE, P., MOCHIZUKI, H., NISHI, T., LEVIN, V., SAYA, H."DIFFERENTIAL SPLICING OF THE NEUROFIBROMATOSIS TYPE-1 GENE IN THE RAT - SPLICE VARIANTS HOMOLOGOUS WITH THE HUMAN ARE EXPRESSED IN RAT-CELLS". International Journal of Oncology 1.2 (1992): 149-152.
Chicago
KYRITSIS, A., LEE, P., MOCHIZUKI, H., NISHI, T., LEVIN, V., SAYA, H."DIFFERENTIAL SPLICING OF THE NEUROFIBROMATOSIS TYPE-1 GENE IN THE RAT - SPLICE VARIANTS HOMOLOGOUS WITH THE HUMAN ARE EXPRESSED IN RAT-CELLS". International Journal of Oncology 1, no. 2 (1992): 149-152. https://doi.org/10.3892/ijo.1.2.149
Copy and paste a formatted citation
x
Spandidos Publications style
KYRITSIS A, LEE P, MOCHIZUKI H, NISHI T, LEVIN V and SAYA H: DIFFERENTIAL SPLICING OF THE NEUROFIBROMATOSIS TYPE-1 GENE IN THE RAT - SPLICE VARIANTS HOMOLOGOUS WITH THE HUMAN ARE EXPRESSED IN RAT-CELLS. Int J Oncol 1: 149-152, 1992.
APA
KYRITSIS, A., LEE, P., MOCHIZUKI, H., NISHI, T., LEVIN, V., & SAYA, H. (1992). DIFFERENTIAL SPLICING OF THE NEUROFIBROMATOSIS TYPE-1 GENE IN THE RAT - SPLICE VARIANTS HOMOLOGOUS WITH THE HUMAN ARE EXPRESSED IN RAT-CELLS. International Journal of Oncology, 1, 149-152. https://doi.org/10.3892/ijo.1.2.149
MLA
KYRITSIS, A., LEE, P., MOCHIZUKI, H., NISHI, T., LEVIN, V., SAYA, H."DIFFERENTIAL SPLICING OF THE NEUROFIBROMATOSIS TYPE-1 GENE IN THE RAT - SPLICE VARIANTS HOMOLOGOUS WITH THE HUMAN ARE EXPRESSED IN RAT-CELLS". International Journal of Oncology 1.2 (1992): 149-152.
Chicago
KYRITSIS, A., LEE, P., MOCHIZUKI, H., NISHI, T., LEVIN, V., SAYA, H."DIFFERENTIAL SPLICING OF THE NEUROFIBROMATOSIS TYPE-1 GENE IN THE RAT - SPLICE VARIANTS HOMOLOGOUS WITH THE HUMAN ARE EXPRESSED IN RAT-CELLS". International Journal of Oncology 1, no. 2 (1992): 149-152. https://doi.org/10.3892/ijo.1.2.149
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