This paper attempts to re-examine the tumor and carcinogenesis-regulating abilities of tissues of several urodele species that are able to regenerate. Regeneration-competent tissues seem refractory to chemical carcinogenesis while this is not the case with regeneration-incompetent tissues. Spontaneous tumors are not readily found and the ones that have been found have not been well characterized. The implications of such resistance to cancer formation at the molecular level are discussed. It is proposed that regulation of embryonic genes, including oncogenes, might be driven by unique events in the regenerating tissues of amphibia. In addtion expression patterns of two oncogenes are presented.

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