MUTATIONS IN AN ALTERNATIVELY SPLICED EXON OF H-RAS ARE NOT ASSOCIATED WITH LOSS OF HETEROZYGOSITY ON CHROMOSOME 11P15.5 IN OVARIAN TUMORIGENESIS

  • Authors:
    • RL FRIEDMAN
    • M VELICESCU
    • L DUBEAU
  • View Affiliations

  • Published online on: July 1, 1992     https://doi.org/10.3892/ijo.1.2.215
  • Pages: 215-219
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Abstract

There is evidence that an alternatively spliced exon of the H-ras gene, called idx is associated with down-regulation of H-ras activity. We tested the hypothesis that mutations in this exon play an important role in the development of ovarian carcinomas because loss of heterozygosity at the H-ras locus is frequently observed in these tumors. The idx sequence of 26 different ovarian carcinomas was amplified by PCR and the products were analyzed for possible mutations by single-stranded conformation polymorphism and DNA sequencing. The results showed no idx mutations, even in tumors with a demonstrable loss of one H-ras allele.

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July 1992
Volume 1 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
FRIEDMAN R, VELICESCU M and DUBEAU L: MUTATIONS IN AN ALTERNATIVELY SPLICED EXON OF H-RAS ARE NOT ASSOCIATED WITH LOSS OF HETEROZYGOSITY ON CHROMOSOME 11P15.5 IN OVARIAN TUMORIGENESIS. Int J Oncol 1: 215-219, 1992
APA
FRIEDMAN, R., VELICESCU, M., & DUBEAU, L. (1992). MUTATIONS IN AN ALTERNATIVELY SPLICED EXON OF H-RAS ARE NOT ASSOCIATED WITH LOSS OF HETEROZYGOSITY ON CHROMOSOME 11P15.5 IN OVARIAN TUMORIGENESIS. International Journal of Oncology, 1, 215-219. https://doi.org/10.3892/ijo.1.2.215
MLA
FRIEDMAN, R., VELICESCU, M., DUBEAU, L."MUTATIONS IN AN ALTERNATIVELY SPLICED EXON OF H-RAS ARE NOT ASSOCIATED WITH LOSS OF HETEROZYGOSITY ON CHROMOSOME 11P15.5 IN OVARIAN TUMORIGENESIS". International Journal of Oncology 1.2 (1992): 215-219.
Chicago
FRIEDMAN, R., VELICESCU, M., DUBEAU, L."MUTATIONS IN AN ALTERNATIVELY SPLICED EXON OF H-RAS ARE NOT ASSOCIATED WITH LOSS OF HETEROZYGOSITY ON CHROMOSOME 11P15.5 IN OVARIAN TUMORIGENESIS". International Journal of Oncology 1, no. 2 (1992): 215-219. https://doi.org/10.3892/ijo.1.2.215