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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 1992 Volume 1 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1992 Volume 1 Issue 2

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CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH

  • Authors:
    • DM BORTNER
    • M ULIVI
    • MC OSTROWSKI

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    Affiliations: DUKE UNIV,MED CTR,DEPT MICROBIOL & IMMUNOL,BOX 3020,DURHAM,NC 27710.
  • Pages: 221-225
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    Published online on: July 1, 1992
       https://doi.org/10.3892/ijo.1.2.221
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Abstract

To begin to understand how ras p21 might be coupled to the human colony stimulating factor-1 receptor (CSF-IR), we compared the signaling properties of a CSF-IR containing a point mutation that converts the tyrosine at position 809 to a phenylalanine residue to signal transduction in cells that co-express the wild-type receptor and the catalytic domain of the GTPase activating protein (GAP(C)). We find that modulation of the immediate early gene c-myc and a delayed early response represented by the retrotransposon NVL3 were selectively impaired in both situations. Further, constitutive expression of c-myc in cells that contain GAP(C) restored CSF-1-dependent signal transduction. The data suggest a model in which information important for mitogenic cell.growth flows from the region of the receptor containing tyrosine 809, through ras p21, to c-myc in the nucleus.

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Copy and paste a formatted citation
Spandidos Publications style
BORTNER D, ULIVI M and OSTROWSKI M: CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH. Int J Oncol 1: 221-225, 1992.
APA
BORTNER, D., ULIVI, M., & OSTROWSKI, M. (1992). CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH. International Journal of Oncology, 1, 221-225. https://doi.org/10.3892/ijo.1.2.221
MLA
BORTNER, D., ULIVI, M., OSTROWSKI, M."CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH". International Journal of Oncology 1.2 (1992): 221-225.
Chicago
BORTNER, D., ULIVI, M., OSTROWSKI, M."CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH". International Journal of Oncology 1, no. 2 (1992): 221-225. https://doi.org/10.3892/ijo.1.2.221
Copy and paste a formatted citation
x
Spandidos Publications style
BORTNER D, ULIVI M and OSTROWSKI M: CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH. Int J Oncol 1: 221-225, 1992.
APA
BORTNER, D., ULIVI, M., & OSTROWSKI, M. (1992). CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH. International Journal of Oncology, 1, 221-225. https://doi.org/10.3892/ijo.1.2.221
MLA
BORTNER, D., ULIVI, M., OSTROWSKI, M."CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH". International Journal of Oncology 1.2 (1992): 221-225.
Chicago
BORTNER, D., ULIVI, M., OSTROWSKI, M."CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH". International Journal of Oncology 1, no. 2 (1992): 221-225. https://doi.org/10.3892/ijo.1.2.221
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