THE EFFECTS OF SHORT-TERM TREATMENT WITH LEVAMISOLE ON CYTOKINES IN VOLUNTEERS AND CANCER-PATIENTS

  • Authors:
    • M DEBRABANDER
    • V ROELS
    • O VOGELS
    • B DEMOEN
    • R DERIDDER
    • E JAGERS
    • A BAISIER
    • R DOOLAEGE
    • R DECOSTER
    • F AERTS
    • J VANDEBROEK
    • J DECREE
    • H VERHAEGEN
    • M DEWAELE
    • W DISTELMANS
    • S VANBELLE
    • G STORME
  • View Affiliations

  • Published online on: August 1, 1992     https://doi.org/10.3892/ijo.1.3.337
  • Pages: 337-340
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Abstract

In search for clues to the potential immunomodulating mechanism of action of levamisole which might be used as monitoring parameters, we have determined a variety of cytokines in the peripheral blood of volunteers and carcinoma patients before and after a single or a 3-day-treatment with 150 mg/day. In cancer patients no changes could be detected 4 days after a 3-day-treatment course in the levels of TNF-alpha, IL-1beta, IL-2 or IL-6. In a placebo-controlled volunteer study the same treatment did not affect the levels of beta2-microglobulin, IL-1beta, IL-1alpha, IL-2 or IL-6. However, 24hr after the last treatment the concentration of neopterin was slightly but significantly increased and the concentration of soluble IL-2 receptors decreased. A single treatment failed to produce such an effect. It is suggested that the measurement of neopterin and soluble IL-2 receptors may provide useful information in future trials.

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August 1992
Volume 1 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
DEBRABANDER M, ROELS V, VOGELS O, DEMOEN B, DERIDDER R, JAGERS E, BAISIER A, DOOLAEGE R, DECOSTER R, AERTS F, AERTS F, et al: THE EFFECTS OF SHORT-TERM TREATMENT WITH LEVAMISOLE ON CYTOKINES IN VOLUNTEERS AND CANCER-PATIENTS. Int J Oncol 1: 337-340, 1992
APA
DEBRABANDER, M., ROELS, V., VOGELS, O., DEMOEN, B., DERIDDER, R., JAGERS, E. ... STORME, G. (1992). THE EFFECTS OF SHORT-TERM TREATMENT WITH LEVAMISOLE ON CYTOKINES IN VOLUNTEERS AND CANCER-PATIENTS. International Journal of Oncology, 1, 337-340. https://doi.org/10.3892/ijo.1.3.337
MLA
DEBRABANDER, M., ROELS, V., VOGELS, O., DEMOEN, B., DERIDDER, R., JAGERS, E., BAISIER, A., DOOLAEGE, R., DECOSTER, R., AERTS, F., VANDEBROEK, J., DECREE, J., VERHAEGEN, H., DEWAELE, M., DISTELMANS, W., VANBELLE, S., STORME, G."THE EFFECTS OF SHORT-TERM TREATMENT WITH LEVAMISOLE ON CYTOKINES IN VOLUNTEERS AND CANCER-PATIENTS". International Journal of Oncology 1.3 (1992): 337-340.
Chicago
DEBRABANDER, M., ROELS, V., VOGELS, O., DEMOEN, B., DERIDDER, R., JAGERS, E., BAISIER, A., DOOLAEGE, R., DECOSTER, R., AERTS, F., VANDEBROEK, J., DECREE, J., VERHAEGEN, H., DEWAELE, M., DISTELMANS, W., VANBELLE, S., STORME, G."THE EFFECTS OF SHORT-TERM TREATMENT WITH LEVAMISOLE ON CYTOKINES IN VOLUNTEERS AND CANCER-PATIENTS". International Journal of Oncology 1, no. 3 (1992): 337-340. https://doi.org/10.3892/ijo.1.3.337