EPIDERMAL GROWTH-FACTOR RECEPTOR AND ERBB2 PROTEIN IN COLORECTAL TISSUE - COMPARISON BETWEEN CANCER AND NORMAL MUCOSA

  • Authors:
    • R DITTADI
    • M GION
    • A BRAZZALE
    • A NOSADINI
    • S MEO
    • C TREMOLADA
    • U SICARI
    • I VINCI
    • G BRUSCAGNIN
  • View Affiliations

  • Published online on: October 1, 1992     https://doi.org/10.3892/ijo.1.5.587
  • Pages: 587-591
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Abstract

Epidermal growth factor receptor (EGFr) and p185neu protein were measured in 55 samples of carcinoma and 55 of normal colorectal mucosa from the same patient, using a ligand binding assay and an ELISA method respectively. The binding characteristics of EGFr were similar in cancer and normal tissue. The concentrations of both EGFr and p185 showed gaussian distribution and were not significantly different between normal and cancer tissue, although a trend toward higher levels of EGFr in normal mucosa was found. Moreover, no significative variations were found in the ratios between cancer and normal tissue after desaturation of the EGFr. No correlations were found between EGFr and p185 and the main clinopathological parameters.

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October 1992
Volume 1 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
DITTADI R, GION M, BRAZZALE A, NOSADINI A, MEO S, TREMOLADA C, SICARI U, VINCI I and BRUSCAGNIN G: EPIDERMAL GROWTH-FACTOR RECEPTOR AND ERBB2 PROTEIN IN COLORECTAL TISSUE - COMPARISON BETWEEN CANCER AND NORMAL MUCOSA. Int J Oncol 1: 587-591, 1992
APA
DITTADI, R., GION, M., BRAZZALE, A., NOSADINI, A., MEO, S., TREMOLADA, C. ... BRUSCAGNIN, G. (1992). EPIDERMAL GROWTH-FACTOR RECEPTOR AND ERBB2 PROTEIN IN COLORECTAL TISSUE - COMPARISON BETWEEN CANCER AND NORMAL MUCOSA. International Journal of Oncology, 1, 587-591. https://doi.org/10.3892/ijo.1.5.587
MLA
DITTADI, R., GION, M., BRAZZALE, A., NOSADINI, A., MEO, S., TREMOLADA, C., SICARI, U., VINCI, I., BRUSCAGNIN, G."EPIDERMAL GROWTH-FACTOR RECEPTOR AND ERBB2 PROTEIN IN COLORECTAL TISSUE - COMPARISON BETWEEN CANCER AND NORMAL MUCOSA". International Journal of Oncology 1.5 (1992): 587-591.
Chicago
DITTADI, R., GION, M., BRAZZALE, A., NOSADINI, A., MEO, S., TREMOLADA, C., SICARI, U., VINCI, I., BRUSCAGNIN, G."EPIDERMAL GROWTH-FACTOR RECEPTOR AND ERBB2 PROTEIN IN COLORECTAL TISSUE - COMPARISON BETWEEN CANCER AND NORMAL MUCOSA". International Journal of Oncology 1, no. 5 (1992): 587-591. https://doi.org/10.3892/ijo.1.5.587