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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1992 Volume 1 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1992 Volume 1 Issue 6

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Article

INFLUENCE OF NUCLEOTIDES FLANKING THE GGAA CORE SEQUENCE ON ETS1 AND ETS2 DNA-BINDING ACTIVITY AND THE MECHANISM OF ETS1 AUTOREGULATION

  • Authors:
    • R ASCIONE
    • DM THOMPSON
    • R THOMAS
    • A PANAYIOTAKIS
    • R RAMSAY
    • M TYMMS
    • I KOLA
    • A SETH

  • View Affiliations / Copyright

    Affiliations: NCI,MOLEC ONCOL LAB,FREDERICK,MD 21702. LUDWIG INST CANC RES,MELBOURNE TUMOR BIOL BRANCH,MELBOURNE,VIC,AUSTRALIA. MONASH UNIV,CTR EARLY HUMAN DEV,MOLEC EMBRYOL & BIRTH DEFECT LAB,CLAYTON,VIC 3168,AUSTRALIA.
  • Pages: 631-637
    |
    Published online on: November 1, 1992
       https://doi.org/10.3892/ijo.1.6.631
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Abstract

The Ets family of genes encode nuclear proteins that activate transcription by binding to a specific purine-rich (GGAA) ets binding sequence (EBS) present in promoters/enhancers of various genes. We have previously shown that over-expression of ets1 via transfection of ets1 expression vectors into NIH3T3 cells induced the expression of the endogenous Ets1 gene. Here we report that the autoregulation occurs as a result of the ets1 protein binding to the EBS-core located in its own promoter. In the present study, we have also identified Ets binding sites in the IL-4, G-CSF (granulocyte colony stimulating factor), and the 2'5' OAS (oligoadenylate synthetase) promoters by binding with Ets1 and Ets2 proteins using electrophoretic mobility shift assays. Interestingly, we have found that the EBS containing T nucleotides on either side of the GGAA core sequence, does not bind Ets1 or Ets2 proteins. Our findings demonstrate that the sequences surrounding the purine core - GGAA- have a profound influence on the binding of Ets proteins.

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Copy and paste a formatted citation
Spandidos Publications style
ASCIONE R, THOMPSON D, THOMAS R, PANAYIOTAKIS A, RAMSAY R, TYMMS M, KOLA I and SETH A: INFLUENCE OF NUCLEOTIDES FLANKING THE GGAA CORE SEQUENCE ON ETS1 AND ETS2 DNA-BINDING ACTIVITY AND THE MECHANISM OF ETS1 AUTOREGULATION. Int J Oncol 1: 631-637, 1992.
APA
ASCIONE, R., THOMPSON, D., THOMAS, R., PANAYIOTAKIS, A., RAMSAY, R., TYMMS, M. ... SETH, A. (1992). INFLUENCE OF NUCLEOTIDES FLANKING THE GGAA CORE SEQUENCE ON ETS1 AND ETS2 DNA-BINDING ACTIVITY AND THE MECHANISM OF ETS1 AUTOREGULATION. International Journal of Oncology, 1, 631-637. https://doi.org/10.3892/ijo.1.6.631
MLA
ASCIONE, R., THOMPSON, D., THOMAS, R., PANAYIOTAKIS, A., RAMSAY, R., TYMMS, M., KOLA, I., SETH, A."INFLUENCE OF NUCLEOTIDES FLANKING THE GGAA CORE SEQUENCE ON ETS1 AND ETS2 DNA-BINDING ACTIVITY AND THE MECHANISM OF ETS1 AUTOREGULATION". International Journal of Oncology 1.6 (1992): 631-637.
Chicago
ASCIONE, R., THOMPSON, D., THOMAS, R., PANAYIOTAKIS, A., RAMSAY, R., TYMMS, M., KOLA, I., SETH, A."INFLUENCE OF NUCLEOTIDES FLANKING THE GGAA CORE SEQUENCE ON ETS1 AND ETS2 DNA-BINDING ACTIVITY AND THE MECHANISM OF ETS1 AUTOREGULATION". International Journal of Oncology 1, no. 6 (1992): 631-637. https://doi.org/10.3892/ijo.1.6.631
Copy and paste a formatted citation
x
Spandidos Publications style
ASCIONE R, THOMPSON D, THOMAS R, PANAYIOTAKIS A, RAMSAY R, TYMMS M, KOLA I and SETH A: INFLUENCE OF NUCLEOTIDES FLANKING THE GGAA CORE SEQUENCE ON ETS1 AND ETS2 DNA-BINDING ACTIVITY AND THE MECHANISM OF ETS1 AUTOREGULATION. Int J Oncol 1: 631-637, 1992.
APA
ASCIONE, R., THOMPSON, D., THOMAS, R., PANAYIOTAKIS, A., RAMSAY, R., TYMMS, M. ... SETH, A. (1992). INFLUENCE OF NUCLEOTIDES FLANKING THE GGAA CORE SEQUENCE ON ETS1 AND ETS2 DNA-BINDING ACTIVITY AND THE MECHANISM OF ETS1 AUTOREGULATION. International Journal of Oncology, 1, 631-637. https://doi.org/10.3892/ijo.1.6.631
MLA
ASCIONE, R., THOMPSON, D., THOMAS, R., PANAYIOTAKIS, A., RAMSAY, R., TYMMS, M., KOLA, I., SETH, A."INFLUENCE OF NUCLEOTIDES FLANKING THE GGAA CORE SEQUENCE ON ETS1 AND ETS2 DNA-BINDING ACTIVITY AND THE MECHANISM OF ETS1 AUTOREGULATION". International Journal of Oncology 1.6 (1992): 631-637.
Chicago
ASCIONE, R., THOMPSON, D., THOMAS, R., PANAYIOTAKIS, A., RAMSAY, R., TYMMS, M., KOLA, I., SETH, A."INFLUENCE OF NUCLEOTIDES FLANKING THE GGAA CORE SEQUENCE ON ETS1 AND ETS2 DNA-BINDING ACTIVITY AND THE MECHANISM OF ETS1 AUTOREGULATION". International Journal of Oncology 1, no. 6 (1992): 631-637. https://doi.org/10.3892/ijo.1.6.631
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