Pulmonary adenocarcinoma angiogenesis

  • Authors:
    • I Takanami
    • F Tanaka
    • T Hashizume
    • S Kodaira
  • View Affiliations

  • Published online on: January 1, 1997     https://doi.org/10.3892/ijo.10.1.101
  • Pages: 101-106
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Abstract

The basic fibroblast growth factor (bFGF), the transforming growth factor (TGF)-beta 1, and the vascular endothelial growth factor (VEGF) expressions have been studied individually and in combinations with the factor 8-related antigen (F8RA) in relation to the microvascular density and prognosis of a pulmonary adenocarcinoma. The findings have revealed that the bFGF, TGF-beta 1 and VEGF expressions all correlated with microvascular density and the prognosis. A reduced expression of all three angiogenic factors correlated with-less tumor angiogenesis and a better prognosis. A multivariate analysis of the three prognostic factors also revealed that the the bFGF expression correlated with survival. These findings indicate that bFGF, TGF-beta 1, and VEGF expressions play important roles in tumor angiogenesis, and that the bFGF expression is a useful prognostic marker for assessing the outcome bf a pulmonary adenocarcinoma.

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January 1997
Volume 10 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Takanami I, Tanaka F, Hashizume T and Kodaira S: Pulmonary adenocarcinoma angiogenesis. Int J Oncol 10: 101-106, 1997
APA
Takanami, I., Tanaka, F., Hashizume, T., & Kodaira, S. (1997). Pulmonary adenocarcinoma angiogenesis. International Journal of Oncology, 10, 101-106. https://doi.org/10.3892/ijo.10.1.101
MLA
Takanami, I., Tanaka, F., Hashizume, T., Kodaira, S."Pulmonary adenocarcinoma angiogenesis". International Journal of Oncology 10.1 (1997): 101-106.
Chicago
Takanami, I., Tanaka, F., Hashizume, T., Kodaira, S."Pulmonary adenocarcinoma angiogenesis". International Journal of Oncology 10, no. 1 (1997): 101-106. https://doi.org/10.3892/ijo.10.1.101