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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 1997 Volume 10 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1997 Volume 10 Issue 1

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Article

Second-look hepatectomy after 5FU arterial infusion in patients with primary unresectable hepatic colorectal metastases

  • Authors:
    • M Kusunoki
    • M Noda
    • H Yanagi
    • H Kotera
    • T Yamamura

  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 107-111
    |
    Published online on: January 1, 1997
       https://doi.org/10.3892/ijo.10.1.107
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Abstract

We treated primary unresectable hepatic colorectal metastases by hepatic arterial chemotherapy (HAC) combined with resection of the tumor. Patients underwent a resection of the primary colorectal tumor and a placement of HAC system, and received a 5-fluorouracil (5FU) administration once a week (320 mg/m(2)/day). Five patients underwent a 'second-look' hepatectomy in this series. Their shrinkage rate of the primary lesion ranged from 80-99%, as seen by computed tomography. The resected liver tumors were characterized as p53-positive and proliferating cell nuclear antigen-positive. The levels of fluorodeoxyuridylate (FdUMP) and thymidylate synthetase inhibition were low in the tumor tissue. These results might reflect a kind of resistance to 5FU therapy. Hepatectomy is one of the possible options to eradicate the residual SFU-resistant component of the malignancy. Our preliminary experience possibly indicates longer survival from combination approach than from HAC alone.

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Copy and paste a formatted citation
Spandidos Publications style
Kusunoki M, Noda M, Yanagi H, Kotera H and Yamamura T: Second-look hepatectomy after 5FU arterial infusion in patients with primary unresectable hepatic colorectal metastases. Int J Oncol 10: 107-111, 1997.
APA
Kusunoki, M., Noda, M., Yanagi, H., Kotera, H., & Yamamura, T. (1997). Second-look hepatectomy after 5FU arterial infusion in patients with primary unresectable hepatic colorectal metastases. International Journal of Oncology, 10, 107-111. https://doi.org/10.3892/ijo.10.1.107
MLA
Kusunoki, M., Noda, M., Yanagi, H., Kotera, H., Yamamura, T."Second-look hepatectomy after 5FU arterial infusion in patients with primary unresectable hepatic colorectal metastases". International Journal of Oncology 10.1 (1997): 107-111.
Chicago
Kusunoki, M., Noda, M., Yanagi, H., Kotera, H., Yamamura, T."Second-look hepatectomy after 5FU arterial infusion in patients with primary unresectable hepatic colorectal metastases". International Journal of Oncology 10, no. 1 (1997): 107-111. https://doi.org/10.3892/ijo.10.1.107
Copy and paste a formatted citation
x
Spandidos Publications style
Kusunoki M, Noda M, Yanagi H, Kotera H and Yamamura T: Second-look hepatectomy after 5FU arterial infusion in patients with primary unresectable hepatic colorectal metastases. Int J Oncol 10: 107-111, 1997.
APA
Kusunoki, M., Noda, M., Yanagi, H., Kotera, H., & Yamamura, T. (1997). Second-look hepatectomy after 5FU arterial infusion in patients with primary unresectable hepatic colorectal metastases. International Journal of Oncology, 10, 107-111. https://doi.org/10.3892/ijo.10.1.107
MLA
Kusunoki, M., Noda, M., Yanagi, H., Kotera, H., Yamamura, T."Second-look hepatectomy after 5FU arterial infusion in patients with primary unresectable hepatic colorectal metastases". International Journal of Oncology 10.1 (1997): 107-111.
Chicago
Kusunoki, M., Noda, M., Yanagi, H., Kotera, H., Yamamura, T."Second-look hepatectomy after 5FU arterial infusion in patients with primary unresectable hepatic colorectal metastases". International Journal of Oncology 10, no. 1 (1997): 107-111. https://doi.org/10.3892/ijo.10.1.107
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