Biological predictors of response to radiotherapy in cervical carcinomas

  • Authors:
    • M Daidone
    • U Ricardi
    • S Veneroni
    • A Faranda
    • E Benini
    • A Urgesi
    • G Sannazzari
    • R Silvestrini
  • View Affiliations

  • Published online on: January 1, 1997     https://doi.org/10.3892/ijo.10.1.41
  • Pages: 41-46
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Abstract

On 21 patients with T1b-T3b tumours subjected to external radiotherapy and brachytherapy, the expression of P53 and glutathione S-transferase pi [GST-pi], immunohistochemically detected, the S-phase cells fraction (H-3-thymidine labeling index, TLI) and DNA content evaluated by image analysis were determined on biopsies before and after the first 10 Gy. P53 accumulation was reduced in 60% of P53-overexpressing tumours and not induced in P53-negative tumours, GST-pi was induced in about 40% of pretreatment GST-pi-negative cases, TLI was reduced in 70% of the cases regardless of pretreatment values, and DNA profiles remained unchanged in two-thirds of the cases. P53 accumulation was a predictor of 3-year relapse-free survival after radiotherapy, followed by GST-pi expression, whereas TLI did not influence prognosis.

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January 1997
Volume 10 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Daidone M, Ricardi U, Veneroni S, Faranda A, Benini E, Urgesi A, Sannazzari G and Silvestrini R: Biological predictors of response to radiotherapy in cervical carcinomas. Int J Oncol 10: 41-46, 1997
APA
Daidone, M., Ricardi, U., Veneroni, S., Faranda, A., Benini, E., Urgesi, A. ... Silvestrini, R. (1997). Biological predictors of response to radiotherapy in cervical carcinomas. International Journal of Oncology, 10, 41-46. https://doi.org/10.3892/ijo.10.1.41
MLA
Daidone, M., Ricardi, U., Veneroni, S., Faranda, A., Benini, E., Urgesi, A., Sannazzari, G., Silvestrini, R."Biological predictors of response to radiotherapy in cervical carcinomas". International Journal of Oncology 10.1 (1997): 41-46.
Chicago
Daidone, M., Ricardi, U., Veneroni, S., Faranda, A., Benini, E., Urgesi, A., Sannazzari, G., Silvestrini, R."Biological predictors of response to radiotherapy in cervical carcinomas". International Journal of Oncology 10, no. 1 (1997): 41-46. https://doi.org/10.3892/ijo.10.1.41