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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 1997 Volume 10 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1997 Volume 10 Issue 1

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Article

Microsatellite instability in early gastric cancer

  • Authors:
    • P Battista
    • R Palmirotta
    • P Vitullo
    • M Veri
    • C Colalongo
    • L Rigoli
    • F Fedele
    • R Caruso
    • C Inferrera
    • F Romano
    • R MarianiCostantini
    • L Frati
    • A Cama

  • View Affiliations / Copyright

    Affiliations: UNIV MESSINA,DIPARTIMENTO PATOL UMANA,MESSINA,ITALY. UNIV ROMA LA SAPIENZA,DIPARTIMENTO MED SPERIMENTALE,I-00185 ROME,ITALY.
  • Pages: 65-70
    |
    Published online on: January 1, 1997
       https://doi.org/10.3892/ijo.10.1.65
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Abstract

Microsatellite replication errors (RERs), consisting in random tumour-associated allele contractions or expansions, represent a frequent genetic alteration in gastric cancer and appear to be associated with important clinicopathologic parameters. To verify the role of microsatellite instability in the initial phases of gastric carcinogenesis, we analysed the status of II microsatellites in paired microdissected samples of tumour and unaffected mucosa from 30 cases of early gastric carcinoma. Fifteen tumours (50%) demonstrated RERs: these included 7 cases with RERs at one locus and 8 cases with RERs at 2 or more loci. Cases with 2 or more RERs were more frequent among intramucosal tumours, compared to tumours with submucosal spread (43% vs. 12%) and among tumours staged T1NOMx, compared to tumours staged T1N1Mx (35% vs. 0%). RER-positive microsatellite typings were statistically more frequent among tumours with intramucosal extension, lower stage (T1NOMx) and excavated growth pattern (macroscopic type III), compared to tumours with submucosal extension, higher stage (T1N1Mx) and elevated, flat or depressed growth patterns (macroscopic types IIa-IIb-IIc respectively). The above findings indicate that microsatellite instability occurs early in the progression of sporadic gastric cancer and tends to be associated with good prognostic indicators.

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Copy and paste a formatted citation
Spandidos Publications style
Battista P, Palmirotta R, Vitullo P, Veri M, Colalongo C, Rigoli L, Fedele F, Caruso R, Inferrera C, Romano F, Romano F, et al: Microsatellite instability in early gastric cancer. Int J Oncol 10: 65-70, 1997.
APA
Battista, P., Palmirotta, R., Vitullo, P., Veri, M., Colalongo, C., Rigoli, L. ... Cama, A. (1997). Microsatellite instability in early gastric cancer. International Journal of Oncology, 10, 65-70. https://doi.org/10.3892/ijo.10.1.65
MLA
Battista, P., Palmirotta, R., Vitullo, P., Veri, M., Colalongo, C., Rigoli, L., Fedele, F., Caruso, R., Inferrera, C., Romano, F., MarianiCostantini, R., Frati, L., Cama, A."Microsatellite instability in early gastric cancer". International Journal of Oncology 10.1 (1997): 65-70.
Chicago
Battista, P., Palmirotta, R., Vitullo, P., Veri, M., Colalongo, C., Rigoli, L., Fedele, F., Caruso, R., Inferrera, C., Romano, F., MarianiCostantini, R., Frati, L., Cama, A."Microsatellite instability in early gastric cancer". International Journal of Oncology 10, no. 1 (1997): 65-70. https://doi.org/10.3892/ijo.10.1.65
Copy and paste a formatted citation
x
Spandidos Publications style
Battista P, Palmirotta R, Vitullo P, Veri M, Colalongo C, Rigoli L, Fedele F, Caruso R, Inferrera C, Romano F, Romano F, et al: Microsatellite instability in early gastric cancer. Int J Oncol 10: 65-70, 1997.
APA
Battista, P., Palmirotta, R., Vitullo, P., Veri, M., Colalongo, C., Rigoli, L. ... Cama, A. (1997). Microsatellite instability in early gastric cancer. International Journal of Oncology, 10, 65-70. https://doi.org/10.3892/ijo.10.1.65
MLA
Battista, P., Palmirotta, R., Vitullo, P., Veri, M., Colalongo, C., Rigoli, L., Fedele, F., Caruso, R., Inferrera, C., Romano, F., MarianiCostantini, R., Frati, L., Cama, A."Microsatellite instability in early gastric cancer". International Journal of Oncology 10.1 (1997): 65-70.
Chicago
Battista, P., Palmirotta, R., Vitullo, P., Veri, M., Colalongo, C., Rigoli, L., Fedele, F., Caruso, R., Inferrera, C., Romano, F., MarianiCostantini, R., Frati, L., Cama, A."Microsatellite instability in early gastric cancer". International Journal of Oncology 10, no. 1 (1997): 65-70. https://doi.org/10.3892/ijo.10.1.65
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