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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 1997 Volume 10 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February 1997 Volume 10 Issue 2

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Article

DPC 4/SMAD 4 in non-pancreatic tumors with frequent LOH 18q21 and in hematological malignancies

  • Authors:
    • W Verbeek
    • K Spirin
    • Y Hatta
    • C Miller
    • N Kawamata
    • S Takeuchi
    • M Koike
    • H Asou
    • J Simpson
    • H Koeffler

  • View Affiliations / Copyright

    Affiliations: CITY HOPE NATL MED CTR,DEPT PATHOL,DUARTE,CA 91010.
  • Pages: 257-260
    |
    Published online on: February 1, 1997
       https://doi.org/10.3892/ijo.10.2.257
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Abstract

Recently, a novel candidate tumor suppressor gene, DPC 4/SMAD 4, has been implicated in the development of pancreatic cancers. Its location at human chromosome 18q21 prompted us to investigate this gene in a large series of primary tumors located outside the gastrointestinal tract which have been associated with loss of heterozygocity (LOH) at this locus. One hundred and thirty primary solid tumor samples (28 breast, 34 non-small cell lung, and 20 prostate cancers, and 40 osteosarcomas), 32 cell lines as well as 162 leukemia and lymphoma cases were analysed by Southern blotting and PCR-SSCP for deletions and mutations of the DPC 4 gene. In the breast cancer cell line MDA-MB-468, the gene was found to be homozygously deleted. Neither the primary solid tumor samples nor hematological malignancies had detectable abnormalities. Our study suggests that alterations of the DPC 4 gene, unlike in pancreatic cancer, are rare in breast, nonsmall cell lung and prostate cancers, osteosarcomas and hematopoietic malignancies.

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Copy and paste a formatted citation
Spandidos Publications style
Verbeek W, Spirin K, Hatta Y, Miller C, Kawamata N, Takeuchi S, Koike M, Asou H, Simpson J, Koeffler H, Koeffler H, et al: DPC 4/SMAD 4 in non-pancreatic tumors with frequent LOH 18q21 and in hematological malignancies. Int J Oncol 10: 257-260, 1997.
APA
Verbeek, W., Spirin, K., Hatta, Y., Miller, C., Kawamata, N., Takeuchi, S. ... Koeffler, H. (1997). DPC 4/SMAD 4 in non-pancreatic tumors with frequent LOH 18q21 and in hematological malignancies. International Journal of Oncology, 10, 257-260. https://doi.org/10.3892/ijo.10.2.257
MLA
Verbeek, W., Spirin, K., Hatta, Y., Miller, C., Kawamata, N., Takeuchi, S., Koike, M., Asou, H., Simpson, J., Koeffler, H."DPC 4/SMAD 4 in non-pancreatic tumors with frequent LOH 18q21 and in hematological malignancies". International Journal of Oncology 10.2 (1997): 257-260.
Chicago
Verbeek, W., Spirin, K., Hatta, Y., Miller, C., Kawamata, N., Takeuchi, S., Koike, M., Asou, H., Simpson, J., Koeffler, H."DPC 4/SMAD 4 in non-pancreatic tumors with frequent LOH 18q21 and in hematological malignancies". International Journal of Oncology 10, no. 2 (1997): 257-260. https://doi.org/10.3892/ijo.10.2.257
Copy and paste a formatted citation
x
Spandidos Publications style
Verbeek W, Spirin K, Hatta Y, Miller C, Kawamata N, Takeuchi S, Koike M, Asou H, Simpson J, Koeffler H, Koeffler H, et al: DPC 4/SMAD 4 in non-pancreatic tumors with frequent LOH 18q21 and in hematological malignancies. Int J Oncol 10: 257-260, 1997.
APA
Verbeek, W., Spirin, K., Hatta, Y., Miller, C., Kawamata, N., Takeuchi, S. ... Koeffler, H. (1997). DPC 4/SMAD 4 in non-pancreatic tumors with frequent LOH 18q21 and in hematological malignancies. International Journal of Oncology, 10, 257-260. https://doi.org/10.3892/ijo.10.2.257
MLA
Verbeek, W., Spirin, K., Hatta, Y., Miller, C., Kawamata, N., Takeuchi, S., Koike, M., Asou, H., Simpson, J., Koeffler, H."DPC 4/SMAD 4 in non-pancreatic tumors with frequent LOH 18q21 and in hematological malignancies". International Journal of Oncology 10.2 (1997): 257-260.
Chicago
Verbeek, W., Spirin, K., Hatta, Y., Miller, C., Kawamata, N., Takeuchi, S., Koike, M., Asou, H., Simpson, J., Koeffler, H."DPC 4/SMAD 4 in non-pancreatic tumors with frequent LOH 18q21 and in hematological malignancies". International Journal of Oncology 10, no. 2 (1997): 257-260. https://doi.org/10.3892/ijo.10.2.257
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