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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 1997 Volume 10 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 1997 Volume 10 Issue 2

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Article

A human xenograft model for testing early events of epithelial neoplastic invasion

  • Authors:
    • J McCandless
    • A Cress
    • I Rabinovitz
    • C Payne
    • G Bowden
    • J Knox
    • R Nagle

  • View Affiliations / Copyright

    Affiliations: UNIV ARIZONA,ARIZONA CANC CTR,DEPT RADIAT ONCOL,TUCSON,AZ 85724. UNIV ARIZONA,DEPT MICROBIOL & IMMUNOL,TUCSON,AZ 85724. UNIV ARIZONA,DEPT PATHOL,TUCSON,AZ 85724. UNIV ARIZONA,ARIZONA RES LABS,DIV BIOTECHNOL,TUCSON,AZ 85724. HARVARD UNIV,SCH MED,DIV GASTROENTEROL,BOSTON,MA 02115. BETH ISRAEL HOSP,DIV GASTROENTEROL,BOSTON,MA 02115.
  • Pages: 279-285
    |
    Published online on: February 1, 1997
       https://doi.org/10.3892/ijo.10.2.279
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Abstract

We report on a model of human prostate tumor cell invasion using the SCID (severe combined immunodeficient) mouse diaphragm. Tumor cells were injected into SCID mice intraperitoneally and the diaphragms harvested three to five weeks later. Electron microscopy showed tumor cell penetration of the mesothelial cell layer and adhesion to the underlying basement membrane on the inferior surface of the mouse diaphragm, where colonies developed. Immunohistochemistry showed invasion by tumor cells through the basement membrane into the muscle of the diaphragm, presence of human tumor cells among the muscle cells and the presence of selected proteins on the invasion front of the tumor cells. Digital image analysis enabled quantitative comparison of events in the metastatic cascade by variants of the tumor cell line and evaluation of the effectiveness of a putative tumor inhibitor. Results suggest that the SCID mouse diaphragm model is a convenient, effective, easily oriented and reproducible in vivo model of the early events associated with human prostate tumor cell invasion.

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Copy and paste a formatted citation
Spandidos Publications style
McCandless J, Cress A, Rabinovitz I, Payne C, Bowden G, Knox J and Nagle R: A human xenograft model for testing early events of epithelial neoplastic invasion. Int J Oncol 10: 279-285, 1997.
APA
McCandless, J., Cress, A., Rabinovitz, I., Payne, C., Bowden, G., Knox, J., & Nagle, R. (1997). A human xenograft model for testing early events of epithelial neoplastic invasion. International Journal of Oncology, 10, 279-285. https://doi.org/10.3892/ijo.10.2.279
MLA
McCandless, J., Cress, A., Rabinovitz, I., Payne, C., Bowden, G., Knox, J., Nagle, R."A human xenograft model for testing early events of epithelial neoplastic invasion". International Journal of Oncology 10.2 (1997): 279-285.
Chicago
McCandless, J., Cress, A., Rabinovitz, I., Payne, C., Bowden, G., Knox, J., Nagle, R."A human xenograft model for testing early events of epithelial neoplastic invasion". International Journal of Oncology 10, no. 2 (1997): 279-285. https://doi.org/10.3892/ijo.10.2.279
Copy and paste a formatted citation
x
Spandidos Publications style
McCandless J, Cress A, Rabinovitz I, Payne C, Bowden G, Knox J and Nagle R: A human xenograft model for testing early events of epithelial neoplastic invasion. Int J Oncol 10: 279-285, 1997.
APA
McCandless, J., Cress, A., Rabinovitz, I., Payne, C., Bowden, G., Knox, J., & Nagle, R. (1997). A human xenograft model for testing early events of epithelial neoplastic invasion. International Journal of Oncology, 10, 279-285. https://doi.org/10.3892/ijo.10.2.279
MLA
McCandless, J., Cress, A., Rabinovitz, I., Payne, C., Bowden, G., Knox, J., Nagle, R."A human xenograft model for testing early events of epithelial neoplastic invasion". International Journal of Oncology 10.2 (1997): 279-285.
Chicago
McCandless, J., Cress, A., Rabinovitz, I., Payne, C., Bowden, G., Knox, J., Nagle, R."A human xenograft model for testing early events of epithelial neoplastic invasion". International Journal of Oncology 10, no. 2 (1997): 279-285. https://doi.org/10.3892/ijo.10.2.279
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