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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1997 Volume 10 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1997 Volume 10 Issue 3

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Article

Frequent expression of MDR1 and MDR3 genes in acute myelocytic leukemia cells with t(8;21) (q22;q22)

  • Authors:
    • M Mizutani
    • M Yamaguchi
    • H Miwa
    • T Kawamura
    • T Okuno
    • K Nishii
    • H Shiku
    • N Kamada
    • K Kita

  • View Affiliations / Copyright

    Affiliations: MIE UNIV,SCH MED,DEPT INTERNAL MED 2,TSU,MIE 514,JAPAN. HIROSHIMA UNIV,SCH MED,NUCL MED & BIOL RES INST,DEPT HEMATOL,HIROSHIMA 734,JAPAN.
  • Pages: 473-479
    |
    Published online on: March 1, 1997
       https://doi.org/10.3892/ijo.10.3.473
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Abstract

Multidrug resistance (MDR) 1 and MDR3 gene expression were examined in acute myelocytic leukemia (AML) cells from 126 Japanese patients. In 119 AML patients at diagnosis 52 were revealed to have P-gp/MDR1 (43.7%). AML cases with t(8;21) had a higher incidence of P-gp expression (13/17; 76.5%) than cases with other karyotypes (33/89; 37.1%) (p=0.0062). CD19(+) cases expressed P-gp frequently (17/25) as did CD7(+) cases (24/35). In 17 CD19(+) AML with P-gp expression, 12 had t(8;21) abnormality. In 68 AML samples examined, MDR3 mRNA was detected in 11 cases, 9 of which had the t(8;21) abnormality. The MDR3(+) t(8;21) AML samples were also positive for CD19. We analyzed P-gp expression at both diagnosis and relapse in 18 AML patients. All 11 P-gp(+) cases at relapse, in which 5 patients were P-gp negative at diagnosis, showed either t(8;21) or CD7 positivity. Our data demonstrated that expression of MDR1 and MDR3 in AML is closely associated with chromosome abnormality t(8;21) and expression of immature lymphoid antigen CD19 as well as CD7. Kasumi-1, a t(8;21) AML cell line, was demonstrated to lose P-gp by the treatment of 1,25(OH)(2)D-3, a monocyte/macropharge differentiation inducer, suggesting the possible contribution to the therapy for AML.

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Copy and paste a formatted citation
Spandidos Publications style
Mizutani M, Yamaguchi M, Miwa H, Kawamura T, Okuno T, Nishii K, Shiku H, Kamada N and Kita K: Frequent expression of MDR1 and MDR3 genes in acute myelocytic leukemia cells with t(8;21) (q22;q22). Int J Oncol 10: 473-479, 1997.
APA
Mizutani, M., Yamaguchi, M., Miwa, H., Kawamura, T., Okuno, T., Nishii, K. ... Kita, K. (1997). Frequent expression of MDR1 and MDR3 genes in acute myelocytic leukemia cells with t(8;21) (q22;q22). International Journal of Oncology, 10, 473-479. https://doi.org/10.3892/ijo.10.3.473
MLA
Mizutani, M., Yamaguchi, M., Miwa, H., Kawamura, T., Okuno, T., Nishii, K., Shiku, H., Kamada, N., Kita, K."Frequent expression of MDR1 and MDR3 genes in acute myelocytic leukemia cells with t(8;21) (q22;q22)". International Journal of Oncology 10.3 (1997): 473-479.
Chicago
Mizutani, M., Yamaguchi, M., Miwa, H., Kawamura, T., Okuno, T., Nishii, K., Shiku, H., Kamada, N., Kita, K."Frequent expression of MDR1 and MDR3 genes in acute myelocytic leukemia cells with t(8;21) (q22;q22)". International Journal of Oncology 10, no. 3 (1997): 473-479. https://doi.org/10.3892/ijo.10.3.473
Copy and paste a formatted citation
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Spandidos Publications style
Mizutani M, Yamaguchi M, Miwa H, Kawamura T, Okuno T, Nishii K, Shiku H, Kamada N and Kita K: Frequent expression of MDR1 and MDR3 genes in acute myelocytic leukemia cells with t(8;21) (q22;q22). Int J Oncol 10: 473-479, 1997.
APA
Mizutani, M., Yamaguchi, M., Miwa, H., Kawamura, T., Okuno, T., Nishii, K. ... Kita, K. (1997). Frequent expression of MDR1 and MDR3 genes in acute myelocytic leukemia cells with t(8;21) (q22;q22). International Journal of Oncology, 10, 473-479. https://doi.org/10.3892/ijo.10.3.473
MLA
Mizutani, M., Yamaguchi, M., Miwa, H., Kawamura, T., Okuno, T., Nishii, K., Shiku, H., Kamada, N., Kita, K."Frequent expression of MDR1 and MDR3 genes in acute myelocytic leukemia cells with t(8;21) (q22;q22)". International Journal of Oncology 10.3 (1997): 473-479.
Chicago
Mizutani, M., Yamaguchi, M., Miwa, H., Kawamura, T., Okuno, T., Nishii, K., Shiku, H., Kamada, N., Kita, K."Frequent expression of MDR1 and MDR3 genes in acute myelocytic leukemia cells with t(8;21) (q22;q22)". International Journal of Oncology 10, no. 3 (1997): 473-479. https://doi.org/10.3892/ijo.10.3.473
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