Cyclooxygenase-2 gene expression in human breast cancer
- M Parrett
- R Harris
- F Joarder
- M Ross
- K Clausen
- F Robertson
Affiliations: OHIO STATE UNIV,DEPT MED MICROBIOL & IMMUNOL,COLL MED,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,DEPT PATHOL,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,SCH PUBL HLTH,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,CTR COMPREHENS CANC,COLUMBUS,OH 43210.
- Published online on: March 1, 1997 https://doi.org/10.3892/ijo.10.3.503
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Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p<0.01), with COX-2 protein localized to tumor cells. These results indicate that COX-2 gene expression may be useful as a molecular biomarker for human breast tumors and may also predict sensitivity to treatment with nonsteroidal anti-inflammatory drugs.