Viral gene mutation as determinant of low grade malignancy of lesions induced by perinatal retrovirus infection
- S Lu
- M Miyauchi
- K Maruyama
Affiliations: CHIBA CANC CTR RES INST,DIV PATHOL,CHUO KU,CHIBA 260,JAPAN.
- Published online on: March 1, 1997 https://doi.org/10.3892/ijo.10.3.539
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Of 108 Wistar/Ma rats perinatally injected with Snyder-Theilen feline sarcoma virus, 75 developed tumors within 60 days (group A), and 25 after more than 117 days (group B). Metastases were detected in 59.1% and 11.8% in group A and B respectively. Antibody to v-fes gene product was found to occur before tumor development in group B and after tumor development in group A. v-Ses was found to be down-regulated and extensively mutated in tumors of group B. These results suggest viral gene mutation as a determinant of low grade malignancy of lesions induced.