Enhancement by hyperthermia of the in vivo antitumour effect of doxorubicin hydrochloride (DOX) and buthionine sulfoximine (BSO)-hydroxyapatite (HAP) complex

  • Authors:
    • M Imamura
    • T Seki
    • K Kunieda
    • T Tamai
    • A Nishimura
    • K Inoue
    • K Harada
  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/ijo.10.5.961
  • Pages: 961-964
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Abstract

We have developed a new type of drug delivery system (DDS) comprising a complex of porous hydroxyapatite (HAP) with the anticancer drug doxorubicin hydrochloride (DOX) and the glutathione inhibitor buthionine sulfoximine (BSO) (DOX and BSO-HAP complex). We then studied the antitumour effect of DOX and BSO-HAP combined with 44 degrees C hyperthermia for 40 min. It was found that in mice this combined treatment suppressed the growth of sarcoma 180 in terms of tumour volume to 36% in comparison viith mice given plain HAP, and was more effective than HAP + hyperthermia or DOX- and BSO-HAP. These results were also confirmed by histological observation.

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May 1997
Volume 10 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Imamura M, Seki T, Kunieda K, Tamai T, Nishimura A, Inoue K and Harada K: Enhancement by hyperthermia of the in vivo antitumour effect of doxorubicin hydrochloride (DOX) and buthionine sulfoximine (BSO)-hydroxyapatite (HAP) complex. Int J Oncol 10: 961-964, 1997
APA
Imamura, M., Seki, T., Kunieda, K., Tamai, T., Nishimura, A., Inoue, K., & Harada, K. (1997). Enhancement by hyperthermia of the in vivo antitumour effect of doxorubicin hydrochloride (DOX) and buthionine sulfoximine (BSO)-hydroxyapatite (HAP) complex. International Journal of Oncology, 10, 961-964. https://doi.org/10.3892/ijo.10.5.961
MLA
Imamura, M., Seki, T., Kunieda, K., Tamai, T., Nishimura, A., Inoue, K., Harada, K."Enhancement by hyperthermia of the in vivo antitumour effect of doxorubicin hydrochloride (DOX) and buthionine sulfoximine (BSO)-hydroxyapatite (HAP) complex". International Journal of Oncology 10.5 (1997): 961-964.
Chicago
Imamura, M., Seki, T., Kunieda, K., Tamai, T., Nishimura, A., Inoue, K., Harada, K."Enhancement by hyperthermia of the in vivo antitumour effect of doxorubicin hydrochloride (DOX) and buthionine sulfoximine (BSO)-hydroxyapatite (HAP) complex". International Journal of Oncology 10, no. 5 (1997): 961-964. https://doi.org/10.3892/ijo.10.5.961