Role of urokinase-type plasminogen activator and inhibitory effect of protease inhibitor in invasion and metastasis of pancreatic cancer

  • Authors:
    • Y Kawazoe
    • T Sawada
    • Y Chung
    • M Sowa
  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/ijo.10.5.983
  • Pages: 983-987
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Abstract

We investigated the association of urokinase-type plasminogen activator (u-PA) with tumor cell invasion and hepatic metastasis using human pancreatic cancer cell lines (SW1990, PANC-1, and RWP-1). We also examined the effect of the protease inhibitor, gabexate mesilate. SW1990 cells showed a higher u-PA activity (41.2 U/ml) in substrate assay and invasiveness (21.6% IV) than PANC-1 (14.3 U/ml, 10.3% IV) and RWP-1 (22.1, 13.5), which correlated with in vivo hepatic metastasis. Gabexate mesilate significantly reduced the u-PA activity, invasiveness, and hepatic metastasis of SW1990 cells. These findings suggest the possible application of protease inhibitors to prevent tumor invasion and metastasis.

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May 1997
Volume 10 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kawazoe Y, Sawada T, Chung Y and Sowa M: Role of urokinase-type plasminogen activator and inhibitory effect of protease inhibitor in invasion and metastasis of pancreatic cancer. Int J Oncol 10: 983-987, 1997.
APA
Kawazoe, Y., Sawada, T., Chung, Y., & Sowa, M. (1997). Role of urokinase-type plasminogen activator and inhibitory effect of protease inhibitor in invasion and metastasis of pancreatic cancer. International Journal of Oncology, 10, 983-987. https://doi.org/10.3892/ijo.10.5.983
MLA
Kawazoe, Y., Sawada, T., Chung, Y., Sowa, M."Role of urokinase-type plasminogen activator and inhibitory effect of protease inhibitor in invasion and metastasis of pancreatic cancer". International Journal of Oncology 10.5 (1997): 983-987.
Chicago
Kawazoe, Y., Sawada, T., Chung, Y., Sowa, M."Role of urokinase-type plasminogen activator and inhibitory effect of protease inhibitor in invasion and metastasis of pancreatic cancer". International Journal of Oncology 10, no. 5 (1997): 983-987. https://doi.org/10.3892/ijo.10.5.983