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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1997 Volume 10 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1997 Volume 10 Issue 6

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Article

Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha

  • Authors:
    • E Weiss
    • U VonReyher
    • W Kittstein
    • P Moller
    • P Krammer
    • F Marks
    • M Gschwendt

  • View Affiliations / Copyright

    Affiliations: GERMAN CANC RES CTR,DIV BIOCHEM TISSUE SPECIF REGULAT,D-69120 HEIDELBERG,GERMANY. GERMAN CANC RES CTR,DIV IMMUNOGENET,D-69120 HEIDELBERG,GERMANY. UNIV ULM,INST PATHOL,D-89081 ULM,GERMANY.
  • Pages: 1119-1123
    |
    Published online on: June 1, 1997
       https://doi.org/10.3892/ijo.10.6.1119
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Abstract

Apoptosis induced by an antibody to CD95/APO-1/FAS in the colon carcinoma cells COLO 205 and HT-29 is suppressed by the phorbol ester TPA. Inhibition is much more effective in COLO 205 than in HT-29 cells. The TPA effect is abrogated by the protein kinase C (PKC)-specific inhibitor Go6983 indicating a role of PKC in this process. Bryostatin 1, unlike TPA, is unable to suppress apoptosis, but inhibits the TPA-induced suppression of apoptosis. TPA also inhibits indomethacin-induced apoptosis in COLO 205 cells. COLO 205 and HT-29 cells contain the PKC isoenzymes alpha, beta(II) delta, epsilon, eta, mu and zeta. Expression and activity of PKC alpha are at least 5 times higher in COLO 205 than in HT-29 cells. This correlates with the fact that inhibition of CD95-mediated apoptosis by TPA is more prominent in COLO 205 than in HT-29 cells. Thus, these findings suggest that PKC alpha has an important role in the TPA-induced inhibition of apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Weiss E, VonReyher U, Kittstein W, Moller P, Krammer P, Marks F and Gschwendt M: Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha. Int J Oncol 10: 1119-1123, 1997.
APA
Weiss, E., VonReyher, U., Kittstein, W., Moller, P., Krammer, P., Marks, F., & Gschwendt, M. (1997). Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha. International Journal of Oncology, 10, 1119-1123. https://doi.org/10.3892/ijo.10.6.1119
MLA
Weiss, E., VonReyher, U., Kittstein, W., Moller, P., Krammer, P., Marks, F., Gschwendt, M."Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha". International Journal of Oncology 10.6 (1997): 1119-1123.
Chicago
Weiss, E., VonReyher, U., Kittstein, W., Moller, P., Krammer, P., Marks, F., Gschwendt, M."Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha". International Journal of Oncology 10, no. 6 (1997): 1119-1123. https://doi.org/10.3892/ijo.10.6.1119
Copy and paste a formatted citation
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Spandidos Publications style
Weiss E, VonReyher U, Kittstein W, Moller P, Krammer P, Marks F and Gschwendt M: Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha. Int J Oncol 10: 1119-1123, 1997.
APA
Weiss, E., VonReyher, U., Kittstein, W., Moller, P., Krammer, P., Marks, F., & Gschwendt, M. (1997). Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha. International Journal of Oncology, 10, 1119-1123. https://doi.org/10.3892/ijo.10.6.1119
MLA
Weiss, E., VonReyher, U., Kittstein, W., Moller, P., Krammer, P., Marks, F., Gschwendt, M."Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha". International Journal of Oncology 10.6 (1997): 1119-1123.
Chicago
Weiss, E., VonReyher, U., Kittstein, W., Moller, P., Krammer, P., Marks, F., Gschwendt, M."Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha". International Journal of Oncology 10, no. 6 (1997): 1119-1123. https://doi.org/10.3892/ijo.10.6.1119
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