Involvement of human T lymphotropic virus type I in human neoplasia
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- Published online on: June 1, 1997 https://doi.org/10.3892/ijo.10.6.1157
- Pages: 1157-1165
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Abstract
Of 211 human tissues analyzed by PCR-SSCP and direct sequencing for HTLV-I genes, 165 (78.2%) gave positive signals. Signals detected in family members of adult T cell leukemia (ATL) patients showed mutations distinct from those in ATL. HTLV-I gene sequences showed variability in same persons examined at different times. Lymphocytes with prototypic HTLV-I genes showed higher sister chromatid exchange following MNNG treatment than those without. Nasopharyngeal carcinomas carrying both HTLV-I and Epstein-Barr virus genes showed markedly abnormal gene product expression. HTLV-I genes in human DNA may cause deregulation of host cell genes upon exposure to carcinogens including viruses.