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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1997 Volume 10 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1997 Volume 10 Issue 6

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Article

Deletion type hepatocyte growth factor has different effects on growth and c-met expression in 10 different human hepatocellular carcinoma cell lines

  • Authors:
    • A Iemura
    • H Yano
    • S Ogasawara
    • R Yamaguchi
    • T Hisaka
    • I Utsunomiya
    • M Kojiro

  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 1167-1172
    |
    Published online on: June 1, 1997
       https://doi.org/10.3892/ijo.10.6.1167
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Abstract

We examined expression of c-met protein, and the mitogenic and morphologic effects of deletion type hepatocyte growth factor (dHGF) by using 10 human hepatocellular carcinoma (HCC) cell lines having different morphologic and biologic features. c-met protein was detected at varying levels in all cells, regardless of the histological grades. Among the 7 lines expressing c-met at high levels, mitogenic effects of dHGF were stimulative for 2 lines; suppressive for 3 lines; and not distinguishable for the other 2 lines. Furthermore, mitogenic effects of dHGF were different in two clonally related cell lines, having different morphologic and biologic features, even though expression of c-met protein was comparable. dHGF induced scattering of cells and morphologic changes in two lines with suppressing and unaffected growth. In the 3 lines expressing c-met at relatively low levels, no remarkable mitogenic or morphogenic effects were detected. These results suggest that the expression levels of c-met protein were not related to the differentiation levels of HCC cells, and dHGF may cause different biological effects on the cells with almost identical c-met protein expression.

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Copy and paste a formatted citation
Spandidos Publications style
Iemura A, Yano H, Ogasawara S, Yamaguchi R, Hisaka T, Utsunomiya I and Kojiro M: Deletion type hepatocyte growth factor has different effects on growth and c-met expression in 10 different human hepatocellular carcinoma cell lines. Int J Oncol 10: 1167-1172, 1997.
APA
Iemura, A., Yano, H., Ogasawara, S., Yamaguchi, R., Hisaka, T., Utsunomiya, I., & Kojiro, M. (1997). Deletion type hepatocyte growth factor has different effects on growth and c-met expression in 10 different human hepatocellular carcinoma cell lines. International Journal of Oncology, 10, 1167-1172. https://doi.org/10.3892/ijo.10.6.1167
MLA
Iemura, A., Yano, H., Ogasawara, S., Yamaguchi, R., Hisaka, T., Utsunomiya, I., Kojiro, M."Deletion type hepatocyte growth factor has different effects on growth and c-met expression in 10 different human hepatocellular carcinoma cell lines". International Journal of Oncology 10.6 (1997): 1167-1172.
Chicago
Iemura, A., Yano, H., Ogasawara, S., Yamaguchi, R., Hisaka, T., Utsunomiya, I., Kojiro, M."Deletion type hepatocyte growth factor has different effects on growth and c-met expression in 10 different human hepatocellular carcinoma cell lines". International Journal of Oncology 10, no. 6 (1997): 1167-1172. https://doi.org/10.3892/ijo.10.6.1167
Copy and paste a formatted citation
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Spandidos Publications style
Iemura A, Yano H, Ogasawara S, Yamaguchi R, Hisaka T, Utsunomiya I and Kojiro M: Deletion type hepatocyte growth factor has different effects on growth and c-met expression in 10 different human hepatocellular carcinoma cell lines. Int J Oncol 10: 1167-1172, 1997.
APA
Iemura, A., Yano, H., Ogasawara, S., Yamaguchi, R., Hisaka, T., Utsunomiya, I., & Kojiro, M. (1997). Deletion type hepatocyte growth factor has different effects on growth and c-met expression in 10 different human hepatocellular carcinoma cell lines. International Journal of Oncology, 10, 1167-1172. https://doi.org/10.3892/ijo.10.6.1167
MLA
Iemura, A., Yano, H., Ogasawara, S., Yamaguchi, R., Hisaka, T., Utsunomiya, I., Kojiro, M."Deletion type hepatocyte growth factor has different effects on growth and c-met expression in 10 different human hepatocellular carcinoma cell lines". International Journal of Oncology 10.6 (1997): 1167-1172.
Chicago
Iemura, A., Yano, H., Ogasawara, S., Yamaguchi, R., Hisaka, T., Utsunomiya, I., Kojiro, M."Deletion type hepatocyte growth factor has different effects on growth and c-met expression in 10 different human hepatocellular carcinoma cell lines". International Journal of Oncology 10, no. 6 (1997): 1167-1172. https://doi.org/10.3892/ijo.10.6.1167
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