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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1997 Volume 10 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1997 Volume 10 Issue 6

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Article

Tumor necrosis factor alpha-induced stimulation of neoplastic progression of preneoplastic, hyperplastic alveolar nodule line C4

  • Authors:
    • S Tsai
    • B Miller
    • R Jones
    • G Heppner

  • View Affiliations / Copyright

    Affiliations: KARMANOS CANC INST,BREAST CANC PROGRAM,DETROIT,MI 48201.
  • Pages: 1209-1215
    |
    Published online on: June 1, 1997
       https://doi.org/10.3892/ijo.10.6.1209
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Abstract

Lymphocytic infiltrates of the mouse mammary preneoplastic, hyperplastic alveolar nodule (HAN) line C4 have elevated reactivity which correlates positively with the progression of HAN to mammary adenocarcinoma. In this study we investigated the hypothesis that the immunoregulatory mechanisms of HAN infiltrating lymphocytes (HILs) on mammary neoplastic progression are mediated, at least in part, by tumor necrosis factor alpha (TNF alpha). C4 HAN epithelial cells express mRNA for both the p55-60 receptor and the p75-80 TNF alpha receptors. High levels of both TNF alpha and TNF beta are expressed by HILs, whereas only TNF alpha is expressed by the C4 HAN epithelial cells. Treatment of C4 HAN bearers with TNF alpha in vivo decreases the latency period and enhances the frequency of HAN progression to tumor. Proliferation of monolayer cultures of epithelial cells from mammary glands of normal and C4 HAN-bearing mice, as well as C4 tumor cells, is enhanced by TNF alpha. Growth of normal mammary cells in 3-dimensional collagen cultures is also significantly stimulated by TNF alpha. Our results suggest that stimulation of epithelial cell proliferation by HIL-produced TNF alpha is one mechanism responsible for the 'immune stimulation' of neoplastic progression in the HAN model.

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Copy and paste a formatted citation
Spandidos Publications style
Tsai S, Miller B, Jones R and Heppner G: Tumor necrosis factor alpha-induced stimulation of neoplastic progression of preneoplastic, hyperplastic alveolar nodule line C4. Int J Oncol 10: 1209-1215, 1997.
APA
Tsai, S., Miller, B., Jones, R., & Heppner, G. (1997). Tumor necrosis factor alpha-induced stimulation of neoplastic progression of preneoplastic, hyperplastic alveolar nodule line C4. International Journal of Oncology, 10, 1209-1215. https://doi.org/10.3892/ijo.10.6.1209
MLA
Tsai, S., Miller, B., Jones, R., Heppner, G."Tumor necrosis factor alpha-induced stimulation of neoplastic progression of preneoplastic, hyperplastic alveolar nodule line C4". International Journal of Oncology 10.6 (1997): 1209-1215.
Chicago
Tsai, S., Miller, B., Jones, R., Heppner, G."Tumor necrosis factor alpha-induced stimulation of neoplastic progression of preneoplastic, hyperplastic alveolar nodule line C4". International Journal of Oncology 10, no. 6 (1997): 1209-1215. https://doi.org/10.3892/ijo.10.6.1209
Copy and paste a formatted citation
x
Spandidos Publications style
Tsai S, Miller B, Jones R and Heppner G: Tumor necrosis factor alpha-induced stimulation of neoplastic progression of preneoplastic, hyperplastic alveolar nodule line C4. Int J Oncol 10: 1209-1215, 1997.
APA
Tsai, S., Miller, B., Jones, R., & Heppner, G. (1997). Tumor necrosis factor alpha-induced stimulation of neoplastic progression of preneoplastic, hyperplastic alveolar nodule line C4. International Journal of Oncology, 10, 1209-1215. https://doi.org/10.3892/ijo.10.6.1209
MLA
Tsai, S., Miller, B., Jones, R., Heppner, G."Tumor necrosis factor alpha-induced stimulation of neoplastic progression of preneoplastic, hyperplastic alveolar nodule line C4". International Journal of Oncology 10.6 (1997): 1209-1215.
Chicago
Tsai, S., Miller, B., Jones, R., Heppner, G."Tumor necrosis factor alpha-induced stimulation of neoplastic progression of preneoplastic, hyperplastic alveolar nodule line C4". International Journal of Oncology 10, no. 6 (1997): 1209-1215. https://doi.org/10.3892/ijo.10.6.1209
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