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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1997 Volume 10 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1997 Volume 10 Issue 6

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Article

Loss of heterozygosity on chromosome 17p13 (p53) and 13q14 (Rb1) in squamous cell carcinoma of head and neck

  • Authors:
    • Y Li
    • Z Pavelic
    • L Wang
    • X Wang
    • L Gleich
    • P Biddinger
    • P Gartside
    • K Wilson
    • J Gluckman
    • P Stambrook

  • View Affiliations / Copyright

    Affiliations: UNIV CINCINNATI,COLL MED,DEPT OTOLARYNGOL HEAD & NECK SURG,DIV MOL ONCOL,CINCINNATI,OH 45267. UNIV CINCINNATI,COLL MED,DEPT PATHOL & LAB MED,CINCINNATI,OH 45267. UNIV CINCINNATI,COLL MED,DEPT CELL BIOL NEUROBIOL & ANAT,CINCINNATI,OH 45267. UNIV CINCINNATI,COLL MED,DEPT ENVIRONM HLTH,CINCINNATI,OH 45267.
  • Pages: 1235-1240
    |
    Published online on: June 1, 1997
       https://doi.org/10.3892/ijo.10.6.1235
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Abstract

Loss of chromosome sequences at 13q14 (Rbl) and 17p13 (p53) associated with squamous cell carcinoma of head and neck (SCCHN) was evaluated in 12 recurrent tumors and 51 primary tumors from 63 patients. The incidence of LOH at 17p13 was 19 of 50 (38%) tumors, and at 13q14 was 21 of 57 (37%). LOH affecting Rbl and/or p53 was observed in 30 of 63 (48%) SCCHN. Coincident LOH at Rbl and p53 was detected in 10 of 46 (22%) tumors. There were nine cases in which primary and metastatic tumors were obtained from the same patient. Of these, seven were informative and five of these (71%) manifested LOH at p53 in both primary and metastatic sites. Examination of Rbl in these same tumors showed LOH in six of the nine metastases, and of these six, only three revealed LOH in the primary tumor. LOH at p53 or Rbl alone showed no correlation with clinical outcome. However, tumors that manifested LOH at both loci were associated with poorer patient outcome and poorer histological differentiation.

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Pavelic Z, Wang L, Wang X, Gleich L, Biddinger P, Gartside P, Wilson K, Gluckman J, Stambrook P, Stambrook P, et al: Loss of heterozygosity on chromosome 17p13 (p53) and 13q14 (Rb1) in squamous cell carcinoma of head and neck. Int J Oncol 10: 1235-1240, 1997.
APA
Li, Y., Pavelic, Z., Wang, L., Wang, X., Gleich, L., Biddinger, P. ... Stambrook, P. (1997). Loss of heterozygosity on chromosome 17p13 (p53) and 13q14 (Rb1) in squamous cell carcinoma of head and neck. International Journal of Oncology, 10, 1235-1240. https://doi.org/10.3892/ijo.10.6.1235
MLA
Li, Y., Pavelic, Z., Wang, L., Wang, X., Gleich, L., Biddinger, P., Gartside, P., Wilson, K., Gluckman, J., Stambrook, P."Loss of heterozygosity on chromosome 17p13 (p53) and 13q14 (Rb1) in squamous cell carcinoma of head and neck". International Journal of Oncology 10.6 (1997): 1235-1240.
Chicago
Li, Y., Pavelic, Z., Wang, L., Wang, X., Gleich, L., Biddinger, P., Gartside, P., Wilson, K., Gluckman, J., Stambrook, P."Loss of heterozygosity on chromosome 17p13 (p53) and 13q14 (Rb1) in squamous cell carcinoma of head and neck". International Journal of Oncology 10, no. 6 (1997): 1235-1240. https://doi.org/10.3892/ijo.10.6.1235
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Pavelic Z, Wang L, Wang X, Gleich L, Biddinger P, Gartside P, Wilson K, Gluckman J, Stambrook P, Stambrook P, et al: Loss of heterozygosity on chromosome 17p13 (p53) and 13q14 (Rb1) in squamous cell carcinoma of head and neck. Int J Oncol 10: 1235-1240, 1997.
APA
Li, Y., Pavelic, Z., Wang, L., Wang, X., Gleich, L., Biddinger, P. ... Stambrook, P. (1997). Loss of heterozygosity on chromosome 17p13 (p53) and 13q14 (Rb1) in squamous cell carcinoma of head and neck. International Journal of Oncology, 10, 1235-1240. https://doi.org/10.3892/ijo.10.6.1235
MLA
Li, Y., Pavelic, Z., Wang, L., Wang, X., Gleich, L., Biddinger, P., Gartside, P., Wilson, K., Gluckman, J., Stambrook, P."Loss of heterozygosity on chromosome 17p13 (p53) and 13q14 (Rb1) in squamous cell carcinoma of head and neck". International Journal of Oncology 10.6 (1997): 1235-1240.
Chicago
Li, Y., Pavelic, Z., Wang, L., Wang, X., Gleich, L., Biddinger, P., Gartside, P., Wilson, K., Gluckman, J., Stambrook, P."Loss of heterozygosity on chromosome 17p13 (p53) and 13q14 (Rb1) in squamous cell carcinoma of head and neck". International Journal of Oncology 10, no. 6 (1997): 1235-1240. https://doi.org/10.3892/ijo.10.6.1235
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