Glutathione S-transferases and cancer (Review)
- D Schipper
- M Wagenmans
- D Wagener
- W Peters
Affiliations: UNIV NIJMEGEN HOSP,DEPT GASTROENTEROL,NL-6500 HB NIJMEGEN,NETHERLANDS. UNIV NIJMEGEN HOSP,DEPT MED ONCOL,NL-6500 HB NIJMEGEN,NETHERLANDS.
- Published online on: June 1, 1997 https://doi.org/10.3892/ijo.10.6.1261
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Cytosolic glutathione S-transferases are a family of enzymes involved in the metabolism of drugs, toxins, carcinogens and also of anticancer drugs. Recent studies have indicated that glutathione S-transferases (GSTs) may play an important role in the resistance of cells to toxins and carcinogens but also to anticancer drugs. This report reviews the current literature concerning the role of glutathione S-transferases in anticancer drug resistance. Moreover, the significance of GST pi in carcinogenesis and its role as prognostic factor is discussed.