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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 1997 Volume 11 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July 1997 Volume 11 Issue 1

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Article

Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms

  • Authors:
    • S Perea
    • O López-Ocejo
    • A von Gabain
    • M De J Araña

  • View Affiliations / Copyright

    Affiliations: UNIV VIENNA,DEPT CELL & MICROBIOL,INST MICROBIOL & GENET,A-1030 VIENNA,AUSTRIA.
  • Pages: 169-173
    |
    Published online on: July 1, 1997
       https://doi.org/10.3892/ijo.11.1.169
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Abstract

Since the IFN system has been implicated in cell growth and differentiation control mechanisms, we evaluated the influence of the expression of HPV-16 E6 and E7 oncoproteins on IFN signaling by using cotransfection experiments. Both viral oncoproteins differentially interfered with the inducibility of IFN-beta promoter by Sendai virus. The activation by IFN-gamma of a GBP ISRE reporter was dramatically affected by both viral proteins suggesting a disruption of STATs/IRFs function. Further, the inducibility of 6-16 gene ISRE reporter by IFN-alpha was decreased to varying degrees by both viral oncoproteins, implying that ISGF3 function is also impaired. Taken together, these observations suggest that HPV-16 negatively interacts with cellular targets of the IFN system, and these interactions may be implicated in cellular transformation caused by HPVs and their refractory response to IFN treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Perea S, López-Ocejo O, von Gabain A and De J Araña M: Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms. Int J Oncol 11: 169-173, 1997.
APA
Perea, S., López-Ocejo, O., von Gabain, A., & De J Araña, M. (1997). Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms. International Journal of Oncology, 11, 169-173. https://doi.org/10.3892/ijo.11.1.169
MLA
Perea, S., López-Ocejo, O., von Gabain, A., De J Araña, M."Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms". International Journal of Oncology 11.1 (1997): 169-173.
Chicago
Perea, S., López-Ocejo, O., von Gabain, A., De J Araña, M."Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms". International Journal of Oncology 11, no. 1 (1997): 169-173. https://doi.org/10.3892/ijo.11.1.169
Copy and paste a formatted citation
x
Spandidos Publications style
Perea S, López-Ocejo O, von Gabain A and De J Araña M: Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms. Int J Oncol 11: 169-173, 1997.
APA
Perea, S., López-Ocejo, O., von Gabain, A., & De J Araña, M. (1997). Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms. International Journal of Oncology, 11, 169-173. https://doi.org/10.3892/ijo.11.1.169
MLA
Perea, S., López-Ocejo, O., von Gabain, A., De J Araña, M."Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms". International Journal of Oncology 11.1 (1997): 169-173.
Chicago
Perea, S., López-Ocejo, O., von Gabain, A., De J Araña, M."Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms". International Journal of Oncology 11, no. 1 (1997): 169-173. https://doi.org/10.3892/ijo.11.1.169
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