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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 1997 Volume 11 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July 1997 Volume 11 Issue 1

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Article

Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma

  • Authors:
    • C Wu
    • N Habib
    • R Mitry
    • P Reitsma
    • S vanDeventer
    • R Chamuleau

  • View Affiliations / Copyright

    Affiliations: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT SURG,LONDON,ENGLAND.
  • Pages: 187-192
    |
    Published online on: July 1, 1997
       https://doi.org/10.3892/ijo.11.1.187
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Abstract

Serum ferritin is elevated in many cancers. Using the subtraction-enhanced display technique, we isolated several cDNA clones including ferritin-H which is overexpressed in rat hepatocellular carcinoma (HCC) induced by diethylnitrosamine. We investigated hepatic messenger RNA (mRNA) levels of ferritin-H in patients with HCC, adenoma, cirrhosis and healthy controls in relation to those of oncogene c-myc. Ferritin-H mRNA levels were 2-12 fold higher in tumor tissues than in adjacent non-tumor tissues in 12 of 17 patients with HCC, irrespective of coexisting cirrhosis or viral hepatitis. However, no difference in ferritin-H mRNA levels was found in patients with adenoma, cirrhosis and healthy controls. c-myc mRNA levels were 2-5 ford increased in 11 of 17 HCC patients, and correlated significantly with those of ferritin-H (p<0.001). In situ hybridization showed that the overexpressed ferritin-H mRNA was restricted to the tumor nodules in HCC livers. These findings suggest that overexpression of ferritin-fl in HCC patients, correlated with c-myc, is phenotypically associated with HCC, and could become a useful molecular indicator for human HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Wu C, Habib N, Mitry R, Reitsma P, vanDeventer S and Chamuleau R: Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma. Int J Oncol 11: 187-192, 1997.
APA
Wu, C., Habib, N., Mitry, R., Reitsma, P., vanDeventer, S., & Chamuleau, R. (1997). Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma. International Journal of Oncology, 11, 187-192. https://doi.org/10.3892/ijo.11.1.187
MLA
Wu, C., Habib, N., Mitry, R., Reitsma, P., vanDeventer, S., Chamuleau, R."Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma". International Journal of Oncology 11.1 (1997): 187-192.
Chicago
Wu, C., Habib, N., Mitry, R., Reitsma, P., vanDeventer, S., Chamuleau, R."Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma". International Journal of Oncology 11, no. 1 (1997): 187-192. https://doi.org/10.3892/ijo.11.1.187
Copy and paste a formatted citation
x
Spandidos Publications style
Wu C, Habib N, Mitry R, Reitsma P, vanDeventer S and Chamuleau R: Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma. Int J Oncol 11: 187-192, 1997.
APA
Wu, C., Habib, N., Mitry, R., Reitsma, P., vanDeventer, S., & Chamuleau, R. (1997). Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma. International Journal of Oncology, 11, 187-192. https://doi.org/10.3892/ijo.11.1.187
MLA
Wu, C., Habib, N., Mitry, R., Reitsma, P., vanDeventer, S., Chamuleau, R."Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma". International Journal of Oncology 11.1 (1997): 187-192.
Chicago
Wu, C., Habib, N., Mitry, R., Reitsma, P., vanDeventer, S., Chamuleau, R."Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma". International Journal of Oncology 11, no. 1 (1997): 187-192. https://doi.org/10.3892/ijo.11.1.187
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