Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma

  • Authors:
    • C Wu
    • N Habib
    • R Mitry
    • P Reitsma
    • S vanDeventer
    • R Chamuleau
  • View Affiliations

  • Published online on: July 1, 1997     https://doi.org/10.3892/ijo.11.1.187
  • Pages: 187-192
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Serum ferritin is elevated in many cancers. Using the subtraction-enhanced display technique, we isolated several cDNA clones including ferritin-H which is overexpressed in rat hepatocellular carcinoma (HCC) induced by diethylnitrosamine. We investigated hepatic messenger RNA (mRNA) levels of ferritin-H in patients with HCC, adenoma, cirrhosis and healthy controls in relation to those of oncogene c-myc. Ferritin-H mRNA levels were 2-12 fold higher in tumor tissues than in adjacent non-tumor tissues in 12 of 17 patients with HCC, irrespective of coexisting cirrhosis or viral hepatitis. However, no difference in ferritin-H mRNA levels was found in patients with adenoma, cirrhosis and healthy controls. c-myc mRNA levels were 2-5 ford increased in 11 of 17 HCC patients, and correlated significantly with those of ferritin-H (p<0.001). In situ hybridization showed that the overexpressed ferritin-H mRNA was restricted to the tumor nodules in HCC livers. These findings suggest that overexpression of ferritin-fl in HCC patients, correlated with c-myc, is phenotypically associated with HCC, and could become a useful molecular indicator for human HCC.

Related Articles

Journal Cover

July 1997
Volume 11 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wu C, Habib N, Mitry R, Reitsma P, vanDeventer S and Chamuleau R: Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma. Int J Oncol 11: 187-192, 1997
APA
Wu, C., Habib, N., Mitry, R., Reitsma, P., vanDeventer, S., & Chamuleau, R. (1997). Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma. International Journal of Oncology, 11, 187-192. https://doi.org/10.3892/ijo.11.1.187
MLA
Wu, C., Habib, N., Mitry, R., Reitsma, P., vanDeventer, S., Chamuleau, R."Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma". International Journal of Oncology 11.1 (1997): 187-192.
Chicago
Wu, C., Habib, N., Mitry, R., Reitsma, P., vanDeventer, S., Chamuleau, R."Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma". International Journal of Oncology 11, no. 1 (1997): 187-192. https://doi.org/10.3892/ijo.11.1.187