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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1997 Volume 11 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 1997 Volume 11 Issue 2

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Article

Familial cancer in Sweden

  • Authors:
    • K Hemminki
    • P Vaittinen

  • View Affiliations / Copyright

    Affiliations: NATL BOARD HLTH & WELF,CTR EPIDEMIOL,S-10630 STOCKHOLM,SWEDEN.
  • Pages: 273-280
    |
    Published online on: August 1, 1997
       https://doi.org/10.3892/ijo.11.2.273
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Abstract

Studies on familial clustering of cancer have usually followed transmission of a trait or mutant gene from one parental line. However, an access to families with two affected parents may additionally contribute to the models of carcinogenesis. The combined effect of parental cancer on the cancer risk of the offspring was tested in a large population-based data set. A family-cancer data base was constructed from the nationwide Swedish registries to include over 21,000 cancers in offspring diagnosed at ages 15-51 and their parents. Cancer risk in the offspring was assessed when the parents had different combinations of site-specific cancers. The risk in the offspring was increased only moderately, at most 1.1 times when the father or the mother had cancer. If both parents had cancer the risks were higher and reached statistical significance for the following paternal/maternal site-specific combinations: colorectum/colorectum, prostate/colorectum, colorectum/breast, prostate/breast, melanoma/breast and skin (squamous cell carcinoma)/breast. These results on young and middle-aged adults indicate that cancer in both parents increase cancer risk in the offspring at many sites. A likely molecular explanation is that both parents contribute with different mutant genes to the set of genes constituting the multistage pathway to carcinogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Hemminki K and Vaittinen P: Familial cancer in Sweden. Int J Oncol 11: 273-280, 1997.
APA
Hemminki, K., & Vaittinen, P. (1997). Familial cancer in Sweden. International Journal of Oncology, 11, 273-280. https://doi.org/10.3892/ijo.11.2.273
MLA
Hemminki, K., Vaittinen, P."Familial cancer in Sweden". International Journal of Oncology 11.2 (1997): 273-280.
Chicago
Hemminki, K., Vaittinen, P."Familial cancer in Sweden". International Journal of Oncology 11, no. 2 (1997): 273-280. https://doi.org/10.3892/ijo.11.2.273
Copy and paste a formatted citation
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Spandidos Publications style
Hemminki K and Vaittinen P: Familial cancer in Sweden. Int J Oncol 11: 273-280, 1997.
APA
Hemminki, K., & Vaittinen, P. (1997). Familial cancer in Sweden. International Journal of Oncology, 11, 273-280. https://doi.org/10.3892/ijo.11.2.273
MLA
Hemminki, K., Vaittinen, P."Familial cancer in Sweden". International Journal of Oncology 11.2 (1997): 273-280.
Chicago
Hemminki, K., Vaittinen, P."Familial cancer in Sweden". International Journal of Oncology 11, no. 2 (1997): 273-280. https://doi.org/10.3892/ijo.11.2.273
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