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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1997 Volume 11 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 1997 Volume 11 Issue 2

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Article

p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms

  • Authors:
    • T Oyama
    • T Kawamoto
    • T Mizoue
    • K Nishida
    • T Osaki
    • K Sugio
    • K Yasumoto
    • T Mitsudomi

  • View Affiliations / Copyright

    Affiliations: UNIV OCCUPAT & ENVIRONM HLTH,DEPT SURG 2,KITAKYUSHU,FUKUOKA 807,JAPAN. UNIV OCCUPAT & ENVIRONM HLTH,DEPT ENVIRONM HLTH,KITAKYUSHU,FUKUOKA 807,JAPAN. UNIV OCCUPAT & ENVIRONM HLTH,DEPT CLIN EPIDEMIOL,KITAKYUSHU,FUKUOKA 807,JAPAN. KYUSHU UNIV,SCH MED,DEPT SURG 2,FUKUOKA 810,JAPAN. AICHI CANC CTR,DEPT THORAC SURG,NAGOYA,AICHI 464,JAPAN.
  • Pages: 305-309
    |
    Published online on: August 1, 1997
       https://doi.org/10.3892/ijo.11.2.305
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Abstract

Cytochrome p4501A1 gene (CYP1A1) and glutathione S-transferase mu gene (GSTM1) are involved in the metabolic activation or detoxification of environmental carcinogens including benzo[a]pyrene in tobacco smoke. Individuals with both Val/Val and C type of CYP1A1 (CYP1A1; Val/Val and CYP1A1; C) or homozygous null (-/-) genotype of GSTM1 gene (GSTM1; -/-) show increased susceptibility to lung cancer. The incidence of p53 gene mutations are related to the smoking index of the lung cancer patients. Therefore we determined genotypes of these enzymes and screened p53 gene mutations in 123 non-small cell lung cancer (NSCLC) patients. p53 gene mutations were found in 35% (43/123) of the patients. The incidence of p53 gene mutation CYP1A1; Val/Val (60.0%), CYP1A1; C (50.0%) tended to be higher than those of CYPIAI; Ile/Ile and Ile/Val (40.4%) or CYP1A1; A and B (40.5%). We conclude that the incidence of the p53 mutations does not seem to be significantly affected by only CYP1A1 or GSTM1 polymorphisms in lung cancer patients.

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Copy and paste a formatted citation
Spandidos Publications style
Oyama T, Kawamoto T, Mizoue T, Nishida K, Osaki T, Sugio K, Yasumoto K and Mitsudomi T: p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms. Int J Oncol 11: 305-309, 1997.
APA
Oyama, T., Kawamoto, T., Mizoue, T., Nishida, K., Osaki, T., Sugio, K. ... Mitsudomi, T. (1997). p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms. International Journal of Oncology, 11, 305-309. https://doi.org/10.3892/ijo.11.2.305
MLA
Oyama, T., Kawamoto, T., Mizoue, T., Nishida, K., Osaki, T., Sugio, K., Yasumoto, K., Mitsudomi, T."p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms". International Journal of Oncology 11.2 (1997): 305-309.
Chicago
Oyama, T., Kawamoto, T., Mizoue, T., Nishida, K., Osaki, T., Sugio, K., Yasumoto, K., Mitsudomi, T."p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms". International Journal of Oncology 11, no. 2 (1997): 305-309. https://doi.org/10.3892/ijo.11.2.305
Copy and paste a formatted citation
x
Spandidos Publications style
Oyama T, Kawamoto T, Mizoue T, Nishida K, Osaki T, Sugio K, Yasumoto K and Mitsudomi T: p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms. Int J Oncol 11: 305-309, 1997.
APA
Oyama, T., Kawamoto, T., Mizoue, T., Nishida, K., Osaki, T., Sugio, K. ... Mitsudomi, T. (1997). p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms. International Journal of Oncology, 11, 305-309. https://doi.org/10.3892/ijo.11.2.305
MLA
Oyama, T., Kawamoto, T., Mizoue, T., Nishida, K., Osaki, T., Sugio, K., Yasumoto, K., Mitsudomi, T."p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms". International Journal of Oncology 11.2 (1997): 305-309.
Chicago
Oyama, T., Kawamoto, T., Mizoue, T., Nishida, K., Osaki, T., Sugio, K., Yasumoto, K., Mitsudomi, T."p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms". International Journal of Oncology 11, no. 2 (1997): 305-309. https://doi.org/10.3892/ijo.11.2.305
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