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The accumulation of H-1 MR-visible lipid in human glioma cells is independent of the cell cycle

  • Authors:
    • E Delikatny
    • T Jeitner

  • View Affiliations

  • Published online on: September 1, 1997     https://doi.org/10.3892/ijo.11.3.543
  • Pages: 543-550
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Abstract

The human glioma cell line, 2607, was observed with proton magnetic resonance spectroscopy (MRS) in the presence of a number of cell-cycle blockers (cysteamine, desferrioxamine, ADR 529). MR spectra of the arrested cells revealed a correlation between the intensity of the lipid methylene resonance at 1.3 ppm and the percentage of cells in G(2)/M. However, subsequent time course studies using ADR 529 on cells partially synchronised by contact inhibition showed that the emergence of the lipid signal in drug-treated cells is not strictly cell cycle dependent but increases with continuing exposure to ADR 529. This indicates that the accumulation of MR-visible lipid arises from drug cell interactions that specifically affect lipid metabolism in a non cell cycle dependent manner.

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September 1997
Volume 11 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
Delikatny E and Delikatny E: The accumulation of H-1 MR-visible lipid in human glioma cells is independent of the cell cycle. Int J Oncol 11: 543-550, 1997
APA
Delikatny, E., & Delikatny, E. (1997). The accumulation of H-1 MR-visible lipid in human glioma cells is independent of the cell cycle. International Journal of Oncology, 11, 543-550. https://doi.org/10.3892/ijo.11.3.543
MLA
Delikatny, E., Jeitner, T."The accumulation of H-1 MR-visible lipid in human glioma cells is independent of the cell cycle". International Journal of Oncology 11.3 (1997): 543-550.
Chicago
Delikatny, E., Jeitner, T."The accumulation of H-1 MR-visible lipid in human glioma cells is independent of the cell cycle". International Journal of Oncology 11, no. 3 (1997): 543-550. https://doi.org/10.3892/ijo.11.3.543