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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1997 Volume 11 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 1997 Volume 11 Issue 4

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Article

Echistatin inhibits Lewis lung carcinoma cell-matrix adhesion in vitro and experimental metastasis in vivo

  • Authors:
    • D Spalleti-Cernia
    • C Squillacioti
    • R Della Morte
    • P Laccetti
    • N Staiano

  • View Affiliations / Copyright

    Affiliations: UNIV NAPLES,DIPARTIMENTO BIOL & PATOL CELLULARE & MOL,CNR,CTR ENDOCRINOL & ONCOL SPERIMENTALE,I-80131 NAPLES,ITALY. UNIV NAPLES,DIPARTIMENTO BIOCHIM & BIOTECNOL MED,FAC MED & CHIRURG,I-80131 NAPLES,ITALY.
  • Pages: 757-763
    |
    Published online on: October 1, 1997
       https://doi.org/10.3892/ijo.11.4.757
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Abstract

Echistatin, a low molecular weight, RGD-containing protein isolated from the venom of Echis carinatus, inhibited Lewis lung carcinoma cell (3LL) adhesion to immobilized fibronectin and laminin. The inhibition was specific, noncytotoxic, dose-dependent and fully reversible. Echistatin showed a stronger activity in inhibiting cell adhesion to fibronectin rather than to laminin and it resulted about 3-fold more effective than kistrin, an other ROD-snake venom protein, in inhibiting 3LL cell attachment to both substrates. The ability of echistatin to modulate experimental metastasis formation in vivo was also evaluated. A 20% inhibition of the lung metastasis spread with respect to controls was observed when 3LL cells and echistatin were coinjected i.m. into male C57BL/6NCr1BR mice. When echistatin was administered i.p. 1 mu g/g of body weight/72 h x 4 doses into mice bearing Lewis lung carcinoma, it promoted only a 15% inhibition of tumor growth but inhibited by 45% lung metastasis formation. These results demonstrate that echistatin is able to inhibit metastasis attachment and spreading in experimental system in vivo independently by its effect on the primary tumor.

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Copy and paste a formatted citation
Spandidos Publications style
Spalleti-Cernia D, Squillacioti C, Della Morte R, Laccetti P and Staiano N: Echistatin inhibits Lewis lung carcinoma cell-matrix adhesion in vitro and experimental metastasis in vivo. Int J Oncol 11: 757-763, 1997.
APA
Spalleti-Cernia, D., Squillacioti, C., Della Morte, R., Laccetti, P., & Staiano, N. (1997). Echistatin inhibits Lewis lung carcinoma cell-matrix adhesion in vitro and experimental metastasis in vivo. International Journal of Oncology, 11, 757-763. https://doi.org/10.3892/ijo.11.4.757
MLA
Spalleti-Cernia, D., Squillacioti, C., Della Morte, R., Laccetti, P., Staiano, N."Echistatin inhibits Lewis lung carcinoma cell-matrix adhesion in vitro and experimental metastasis in vivo". International Journal of Oncology 11.4 (1997): 757-763.
Chicago
Spalleti-Cernia, D., Squillacioti, C., Della Morte, R., Laccetti, P., Staiano, N."Echistatin inhibits Lewis lung carcinoma cell-matrix adhesion in vitro and experimental metastasis in vivo". International Journal of Oncology 11, no. 4 (1997): 757-763. https://doi.org/10.3892/ijo.11.4.757
Copy and paste a formatted citation
x
Spandidos Publications style
Spalleti-Cernia D, Squillacioti C, Della Morte R, Laccetti P and Staiano N: Echistatin inhibits Lewis lung carcinoma cell-matrix adhesion in vitro and experimental metastasis in vivo. Int J Oncol 11: 757-763, 1997.
APA
Spalleti-Cernia, D., Squillacioti, C., Della Morte, R., Laccetti, P., & Staiano, N. (1997). Echistatin inhibits Lewis lung carcinoma cell-matrix adhesion in vitro and experimental metastasis in vivo. International Journal of Oncology, 11, 757-763. https://doi.org/10.3892/ijo.11.4.757
MLA
Spalleti-Cernia, D., Squillacioti, C., Della Morte, R., Laccetti, P., Staiano, N."Echistatin inhibits Lewis lung carcinoma cell-matrix adhesion in vitro and experimental metastasis in vivo". International Journal of Oncology 11.4 (1997): 757-763.
Chicago
Spalleti-Cernia, D., Squillacioti, C., Della Morte, R., Laccetti, P., Staiano, N."Echistatin inhibits Lewis lung carcinoma cell-matrix adhesion in vitro and experimental metastasis in vivo". International Journal of Oncology 11, no. 4 (1997): 757-763. https://doi.org/10.3892/ijo.11.4.757
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