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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1997 Volume 11 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 1997 Volume 11 Issue 4

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Article

Growth stimulatory effect of interleukin (IL)-1 alpha produced by oral squamous carcinoma cell lines

  • Authors:
    • R Ito
    • W Yasui
    • H Yokozaki
    • U Yamashita
    • T Takata
    • H Nikai
    • E Tahara

  • View Affiliations / Copyright

    Affiliations: HIROSHIMA UNIV,SCH MED,DEPT PATHOL 1,MINAMI KU,HIROSHIMA 734,JAPAN. HIROSHIMA UNIV,SCH MED,DEPT PARASITOL,MINAMI KU,HIROSHIMA 734,JAPAN. HIROSHIMA UNIV,SCH DENT,DEPT ORAL PATHOL,MINAMI KU,HIROSHIMA 734,JAPAN.
  • Pages: 807-812
    |
    Published online on: October 1, 1997
       https://doi.org/10.3892/ijo.11.4.807
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Abstract

The expression of IL-1 alpha and its effect on the cell growth were examined in six human oral squamous carcinoma cell lines. All the cell lines expressed IL-1 alpha mRNA and protein at various levels. Particularly, HSC-2 and HSC-3 cells showed high level of the mRNA expression and secreted large amounts of IL-1 alpha into the culture fluid. Scatchard plot analysis of IL-1 alpha binding revealed that HSC-2 cells had high-and low-affinity receptors, whereas IL-1 alpha receptors on HSC-3 cells were of undetectable level. The cell growth of HSC-2 and HSC-3 cells was stimulated by IL-1 alpha and inhibited by anti-IL-1 alpha antibody or IL-1 receptor antagonist. The expression of IL-1 alpha mRNA by these cell lines was induced by either IL-1 alpha, epidermal growth factor (EGF) or transforming growth factor alpha (TGF-alpha). On the other hand, IL-1 alpha promoted the mRNA expression of TGF-alpha and EGF receptor. These findings indicate that IL-1 alpha acts as an autocrine growth stimulator for oral squamous carcinoma cells in vitro and its interaction with EGF/TGF-alpha/receptor system may play a role in this enhanced growth by IL-1 alpha.

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Copy and paste a formatted citation
Spandidos Publications style
Ito R, Yasui W, Yokozaki H, Yamashita U, Takata T, Nikai H and Tahara E: Growth stimulatory effect of interleukin (IL)-1 alpha produced by oral squamous carcinoma cell lines. Int J Oncol 11: 807-812, 1997.
APA
Ito, R., Yasui, W., Yokozaki, H., Yamashita, U., Takata, T., Nikai, H., & Tahara, E. (1997). Growth stimulatory effect of interleukin (IL)-1 alpha produced by oral squamous carcinoma cell lines. International Journal of Oncology, 11, 807-812. https://doi.org/10.3892/ijo.11.4.807
MLA
Ito, R., Yasui, W., Yokozaki, H., Yamashita, U., Takata, T., Nikai, H., Tahara, E."Growth stimulatory effect of interleukin (IL)-1 alpha produced by oral squamous carcinoma cell lines". International Journal of Oncology 11.4 (1997): 807-812.
Chicago
Ito, R., Yasui, W., Yokozaki, H., Yamashita, U., Takata, T., Nikai, H., Tahara, E."Growth stimulatory effect of interleukin (IL)-1 alpha produced by oral squamous carcinoma cell lines". International Journal of Oncology 11, no. 4 (1997): 807-812. https://doi.org/10.3892/ijo.11.4.807
Copy and paste a formatted citation
x
Spandidos Publications style
Ito R, Yasui W, Yokozaki H, Yamashita U, Takata T, Nikai H and Tahara E: Growth stimulatory effect of interleukin (IL)-1 alpha produced by oral squamous carcinoma cell lines. Int J Oncol 11: 807-812, 1997.
APA
Ito, R., Yasui, W., Yokozaki, H., Yamashita, U., Takata, T., Nikai, H., & Tahara, E. (1997). Growth stimulatory effect of interleukin (IL)-1 alpha produced by oral squamous carcinoma cell lines. International Journal of Oncology, 11, 807-812. https://doi.org/10.3892/ijo.11.4.807
MLA
Ito, R., Yasui, W., Yokozaki, H., Yamashita, U., Takata, T., Nikai, H., Tahara, E."Growth stimulatory effect of interleukin (IL)-1 alpha produced by oral squamous carcinoma cell lines". International Journal of Oncology 11.4 (1997): 807-812.
Chicago
Ito, R., Yasui, W., Yokozaki, H., Yamashita, U., Takata, T., Nikai, H., Tahara, E."Growth stimulatory effect of interleukin (IL)-1 alpha produced by oral squamous carcinoma cell lines". International Journal of Oncology 11, no. 4 (1997): 807-812. https://doi.org/10.3892/ijo.11.4.807
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