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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1997 Volume 11 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 1997 Volume 11 Issue 5

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Article

Aberrant expression of p53 and retinoblastoma gene products in human esophageal squamous cell carcinoma

  • Authors:
    • T Ishikawa
    • M Furihata
    • Y Ohtsuki
    • H Ono
    • A Inoue
    • S Ogoshi

  • View Affiliations / Copyright

    Affiliations: KOCHI MED SCH,DEPT PATHOL 2,NANKO KU,KOCHI 783,JAPAN. KOCHI MED SCH,DEPT SURG 2,NANKO KU,KOCHI 783,JAPAN.
  • Pages: 1109-1114
    |
    Published online on: November 1, 1997
       https://doi.org/10.3892/ijo.11.5.1109
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Abstract

The aberrant expression of p53 and RB proteins was investigated by immunohistochemistry in 73 patients with esophageal SCC, who underwent esophageal resection. Fresh tumor tissues from 21 patients were also tested for p53 mutations in exons 4 through 9 by direct sequencing. Positive nuclear staining with p53 antibody in cancer cells was found in 49.3% (36/73) of the tumors. Mutations in the p53 gene were detected in 66.7% (14/21) by direct sequencing. Nuclear staining with RB antibody in cancer cells was diffuse in 11.0% (8/73) and heterogeneous in 57.5% (42/73) of cases. Ten patients with p53-positive but RB-negative tumors had a significantly higher incidence of stage IV disease than the other patients studied. In addition, 8 patients with tumors with diffuse nuclear staining for RB antibody had a significantly lower survival rate than the other patients. These findings demonstrate that aberrant expression of RB and/or p53 protein is frequent in human esophageal SCC, and is probably associated with tumor progression and unfavorable prognosis.

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Copy and paste a formatted citation
Spandidos Publications style
Ishikawa T, Furihata M, Ohtsuki Y, Ono H, Inoue A and Ogoshi S: Aberrant expression of p53 and retinoblastoma gene products in human esophageal squamous cell carcinoma. Int J Oncol 11: 1109-1114, 1997.
APA
Ishikawa, T., Furihata, M., Ohtsuki, Y., Ono, H., Inoue, A., & Ogoshi, S. (1997). Aberrant expression of p53 and retinoblastoma gene products in human esophageal squamous cell carcinoma. International Journal of Oncology, 11, 1109-1114. https://doi.org/10.3892/ijo.11.5.1109
MLA
Ishikawa, T., Furihata, M., Ohtsuki, Y., Ono, H., Inoue, A., Ogoshi, S."Aberrant expression of p53 and retinoblastoma gene products in human esophageal squamous cell carcinoma". International Journal of Oncology 11.5 (1997): 1109-1114.
Chicago
Ishikawa, T., Furihata, M., Ohtsuki, Y., Ono, H., Inoue, A., Ogoshi, S."Aberrant expression of p53 and retinoblastoma gene products in human esophageal squamous cell carcinoma". International Journal of Oncology 11, no. 5 (1997): 1109-1114. https://doi.org/10.3892/ijo.11.5.1109
Copy and paste a formatted citation
x
Spandidos Publications style
Ishikawa T, Furihata M, Ohtsuki Y, Ono H, Inoue A and Ogoshi S: Aberrant expression of p53 and retinoblastoma gene products in human esophageal squamous cell carcinoma. Int J Oncol 11: 1109-1114, 1997.
APA
Ishikawa, T., Furihata, M., Ohtsuki, Y., Ono, H., Inoue, A., & Ogoshi, S. (1997). Aberrant expression of p53 and retinoblastoma gene products in human esophageal squamous cell carcinoma. International Journal of Oncology, 11, 1109-1114. https://doi.org/10.3892/ijo.11.5.1109
MLA
Ishikawa, T., Furihata, M., Ohtsuki, Y., Ono, H., Inoue, A., Ogoshi, S."Aberrant expression of p53 and retinoblastoma gene products in human esophageal squamous cell carcinoma". International Journal of Oncology 11.5 (1997): 1109-1114.
Chicago
Ishikawa, T., Furihata, M., Ohtsuki, Y., Ono, H., Inoue, A., Ogoshi, S."Aberrant expression of p53 and retinoblastoma gene products in human esophageal squamous cell carcinoma". International Journal of Oncology 11, no. 5 (1997): 1109-1114. https://doi.org/10.3892/ijo.11.5.1109
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