Enhancement of thermal damage in murine tumors by hydralazine-induced modification of blood flow and oxygen tension

Aoki,Y; Akagi,K; Oshima,T; Isoda,H; Nasu,R; Shiga,T; Murata,T; Tanaka,Y

doi:10.3892/ijo.11.5.1123

November 1997 Volume 11 Issue 5

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November 1997 Volume 11 Issue 5

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Article

Enhancement of thermal damage in murine tumors by hydralazine-induced modification of blood flow and oxygen tension

Authors:
- Y Aoki
- K Akagi
- T Oshima
- H Isoda
- R Nasu
- T Shiga
- T Murata
- Y Tanaka
View Affiliations / Copyright

Affiliations: Affliations not specified
Pages: 1123-1128
|
Published online on: November 1, 1997

https://doi.org/10.3892/ijo.11.5.1123
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Abstract

We investigated changes in blood flow in normal muscle and in SCC-VII tumors treated by hyperthermia combined with hydralazine, to evaluate the enhancement of thermal tumor damage by hydralazine. We studied SCC-VII tumor-bearing C3H/He mice. Hydralazine was administered by intraperitoneal injection, and tumors were heated by a water bath. We measured blood flow using the laser Doppler method, and oxygen tension using polarography. The response of tumors to therapy was assessed using a growth delay analysis. In tumors, blood flow and O-2 tension significantly decreased with increasing doses of hydralazine. Compared to tumors treated by hydralazine alone or by hyperthermia alone, tumor blood flow was significantly decreased in the group treated by hyperthermia with hydralazine. In tumors treated by hyperthermia with hydralazine, blood flow was significantly decreased with increasing Hyd doses, heat durations, and temperatures. In normal muscle, no decrease in blood flow was induced by hyperthermia, hydralazine, or their combination. In tumors treated by hyperthermia (43 degrees C, 20 min) with hydralazine, a maximum additional growth delay was observed. Our results suggest that a decrease in tumor blood flow caused by hydralazine plays an important role in enhancement of the hyperthermic antitumor effect.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Enhancement of thermal damage in murine tumors by hydralazine-induced modification of blood flow and oxygen tension

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Abstract

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