Correlation between apoptosis and tumor-associated macrophages in human invasive ductal breast carcinoma

Kruger,S; Fahrenkrog,T; Muller,H

doi:10.3892/ijo.11.5.989

November 1997 Volume 11 Issue 5

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November 1997 Volume 11 Issue 5

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Article

Correlation between apoptosis and tumor-associated macrophages in human invasive ductal breast carcinoma

Authors:
- S Kruger
- T Fahrenkrog
- H Muller
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Affiliations: Affliations not specified
Pages: 989-992
|
Published online on: November 1, 1997

https://doi.org/10.3892/ijo.11.5.989
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Abstract

The relationship between apoptosis and tumor-associated macrophages (TAM) was studied in situ in 60 breast carcinomas (18 G1, 28 G2 and 14 G3 carcinomas) using simultaneous apoptosis (TUNEL method) and macrophage staining (anti-CD68 antibody). Apoptotic tumor cell rate (ATCR), total TAM content (TAM(TOT)) and the proportion of TAM that had either cell-to-cell contact with apoptotic tumor cells or that were phagocytosing them (TAM/APO cells) were quantified. ATCR correlated significantly with TAM(TOT). Within all apoptotic tumor cells, the proportion of TAM/APO cells was lower than 20%. Considering the fact that cell-to-cell contact is essential for macrophage-mediated tumor cell killing, our data suggest that the majority of apoptoses occurring in breast cancer may not be caused by macrophage tumoricidal activity. TAM/APO cells accounted for only 1.7% of all TAM. Thus, tumor cell killing and apoptotic tumor cell phagocytosis seem to be quantitatively less important functions of TAM in human breast cancer in vivo.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation between apoptosis and tumor-associated macrophages in human invasive ductal breast carcinoma

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Abstract

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