Radiation induced G2/M block and apoptosis in two human sarcoma cell lines with different p53 gene status

  • Authors:
    • M Bache
    • J Dunst
    • P Wurl
    • D Frode
    • M Dietzel
    • A Meye
    • H Schmidt
    • F Rath
    • W Wohlrab
    • H Dralle
    • H Taubert
  • View Affiliations

  • Published online on: November 1, 1997     https://doi.org/10.3892/ijo.11.5.993
  • Pages: 993-997
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Abstract

We investigated a wild-type (wt) p53 rhabdomyosarcoma (A-204) and a mutated (mt p53) undifferentiated sarcoma cell line (US8-93) for their response to X-rays. The observation period was 0 to 96 h after irradiation. Both cell lines showed a strikingly delayed G2/M arrest and an induction of apoptosis after irradiation. Compared with the cell line A-204 (wt p53), the cell line US8-93 (mt p53) revealed a stronger G2/M arrest. In agreement with this, in terms of viability as well as the rate of apoptosis, A-204 (wt p53) showed a stronger response to irradiation than US8-93 (mt p53). We suggest that the different p53 gene status might be the cause for a different response to irradiation.

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November 1997
Volume 11 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Bache M, Dunst J, Wurl P, Frode D, Dietzel M, Meye A, Schmidt H, Rath F, Wohlrab W, Dralle H, Dralle H, et al: Radiation induced G2/M block and apoptosis in two human sarcoma cell lines with different p53 gene status. Int J Oncol 11: 993-997, 1997
APA
Bache, M., Dunst, J., Wurl, P., Frode, D., Dietzel, M., Meye, A. ... Taubert, H. (1997). Radiation induced G2/M block and apoptosis in two human sarcoma cell lines with different p53 gene status. International Journal of Oncology, 11, 993-997. https://doi.org/10.3892/ijo.11.5.993
MLA
Bache, M., Dunst, J., Wurl, P., Frode, D., Dietzel, M., Meye, A., Schmidt, H., Rath, F., Wohlrab, W., Dralle, H., Taubert, H."Radiation induced G2/M block and apoptosis in two human sarcoma cell lines with different p53 gene status". International Journal of Oncology 11.5 (1997): 993-997.
Chicago
Bache, M., Dunst, J., Wurl, P., Frode, D., Dietzel, M., Meye, A., Schmidt, H., Rath, F., Wohlrab, W., Dralle, H., Taubert, H."Radiation induced G2/M block and apoptosis in two human sarcoma cell lines with different p53 gene status". International Journal of Oncology 11, no. 5 (1997): 993-997. https://doi.org/10.3892/ijo.11.5.993