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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 1997 Volume 11 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 1997 Volume 11 Issue 6

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Article

Mutational state of tumor suppressor genes (DCC, DPC4) and alteration on chromosome 18q21 in human oral cancer

  • Authors:
    • T Watanabe
    • X Wang
    • A Miyakawa
    • M Shiiba
    • Y Imai
    • T Sato
    • H Tanzawa

  • View Affiliations

    Affiliations: CHIBA UNIV,SCH MED,DEPT ORAL SURG,CHUO KU,CHIBA 260,JAPAN. CHIBA UNIV,SCH MED,DEPT PEDIAT,CHIBA 260,JAPAN. DOKKYO UNIV,SCH MED,DEPT ORAL SURG,MIBU,TOCHIGI,JAPAN.
  • Published online on: December 1, 1997     https://doi.org/10.3892/ijo.11.6.1287
  • Pages: 1287-1290
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Abstract

In order to investigate the roles of two candidate tumor suppressor genes, DCC (deleted in colorectal carcinoma) and DPC4 (deleted in pancreatic carcinoma 4) genes in oral squamous cell carcinoma (SCC), we examined 32 primary SCCs by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. Additionally, 32 pairs of normal and tumor DNA from 32 patients with oral SCCs were also analyzed for loss of heterozygosity (LOH) using 10 microsatellite markers on chromosome 18q21 where DCC and DPC4 genes are localized. We detected point mutations of DPC4 gene in two cases by PCR-SSCP analysis and sequencing. One case showed an AGC (Ser) to ACC (Thr) missense mutation at codon 1061 and the other the substitution C for A of the intron between exons 7 and 8. No mutation of DCC gene was observed in our cases. LOH at 18q21 was observed in 14 of the 32 cases (43.8%). The highest frequency (33.3%) of LOH was found at D18S46, and this was significantly correlated with the pathological results. These findings suggest that DCC and DPC4 gene may play minor roles in the genesis of oral SCC, and that another tumor suppressor gene involved in the development of oral SCC may exist in the region of D18S46 of this chromosome.

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Copy and paste a formatted citation
Spandidos Publications style
Watanabe T, Wang X, Miyakawa A, Shiiba M, Imai Y, Sato T and Tanzawa H: Mutational state of tumor suppressor genes (DCC, DPC4) and alteration on chromosome 18q21 in human oral cancer. Int J Oncol 11: 1287-1290, 1997.
APA
Watanabe, T., Wang, X., Miyakawa, A., Shiiba, M., Imai, Y., Sato, T., & Tanzawa, H. (1997). Mutational state of tumor suppressor genes (DCC, DPC4) and alteration on chromosome 18q21 in human oral cancer. International Journal of Oncology, 11, 1287-1290. https://doi.org/10.3892/ijo.11.6.1287
MLA
Watanabe, T., Wang, X., Miyakawa, A., Shiiba, M., Imai, Y., Sato, T., Tanzawa, H."Mutational state of tumor suppressor genes (DCC, DPC4) and alteration on chromosome 18q21 in human oral cancer". International Journal of Oncology 11.6 (1997): 1287-1290.
Chicago
Watanabe, T., Wang, X., Miyakawa, A., Shiiba, M., Imai, Y., Sato, T., Tanzawa, H."Mutational state of tumor suppressor genes (DCC, DPC4) and alteration on chromosome 18q21 in human oral cancer". International Journal of Oncology 11, no. 6 (1997): 1287-1290. https://doi.org/10.3892/ijo.11.6.1287
Copy and paste a formatted citation
x
Spandidos Publications style
Watanabe T, Wang X, Miyakawa A, Shiiba M, Imai Y, Sato T and Tanzawa H: Mutational state of tumor suppressor genes (DCC, DPC4) and alteration on chromosome 18q21 in human oral cancer. Int J Oncol 11: 1287-1290, 1997.
APA
Watanabe, T., Wang, X., Miyakawa, A., Shiiba, M., Imai, Y., Sato, T., & Tanzawa, H. (1997). Mutational state of tumor suppressor genes (DCC, DPC4) and alteration on chromosome 18q21 in human oral cancer. International Journal of Oncology, 11, 1287-1290. https://doi.org/10.3892/ijo.11.6.1287
MLA
Watanabe, T., Wang, X., Miyakawa, A., Shiiba, M., Imai, Y., Sato, T., Tanzawa, H."Mutational state of tumor suppressor genes (DCC, DPC4) and alteration on chromosome 18q21 in human oral cancer". International Journal of Oncology 11.6 (1997): 1287-1290.
Chicago
Watanabe, T., Wang, X., Miyakawa, A., Shiiba, M., Imai, Y., Sato, T., Tanzawa, H."Mutational state of tumor suppressor genes (DCC, DPC4) and alteration on chromosome 18q21 in human oral cancer". International Journal of Oncology 11, no. 6 (1997): 1287-1290. https://doi.org/10.3892/ijo.11.6.1287
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