A new polyoxometalate complex inhibits retrovirus encoded reverse transcriptase activity in vitro and in vivo.

  • Authors:
    • C Schoeberl
    • R Boehner
    • B Krebs
    • C Mueller
    • A Barnekow
  • View Affiliations

  • Published online on: January 1, 1998     https://doi.org/10.3892/ijo.12.1.153
  • Pages: 153-162
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Abstract

We examined the recently synthesized and characterized polyoxometalate compound (NH4)10[Co2Sb2W20 O70(H2O)6] (POM1). The inhibitory potency of POM1 was studied in tissue culture experiments with uninfected and Rous sarcoma virus (RSV)-infected chicken embryo fibroblasts (CEF) in vivo. We measured a considerable decrease in total cellular phosphotyrosine content in treated infected cells in vivo. POM1 treatment of SR-RSV-A infected CEF in vivo resulted in decreased pp60v-src activity, possibly due to a reduced rate of v-src translation caused by the inhibitory effect of POM1 on the RSV encoded reverse transcriptase activity (RT) activity. In further studies we were able to demonstrate the inhibitory effect of this complex on the RT activity of RSV in vitro and in vivo.

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Jan 1998
Volume 12 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Schoeberl C, Boehner R, Krebs B, Mueller C and Barnekow A: A new polyoxometalate complex inhibits retrovirus encoded reverse transcriptase activity in vitro and in vivo.. Int J Oncol 12: 153-162, 1998
APA
Schoeberl, C., Boehner, R., Krebs, B., Mueller, C., & Barnekow, A. (1998). A new polyoxometalate complex inhibits retrovirus encoded reverse transcriptase activity in vitro and in vivo.. International Journal of Oncology, 12, 153-162. https://doi.org/10.3892/ijo.12.1.153
MLA
Schoeberl, C., Boehner, R., Krebs, B., Mueller, C., Barnekow, A."A new polyoxometalate complex inhibits retrovirus encoded reverse transcriptase activity in vitro and in vivo.". International Journal of Oncology 12.1 (1998): 153-162.
Chicago
Schoeberl, C., Boehner, R., Krebs, B., Mueller, C., Barnekow, A."A new polyoxometalate complex inhibits retrovirus encoded reverse transcriptase activity in vitro and in vivo.". International Journal of Oncology 12, no. 1 (1998): 153-162. https://doi.org/10.3892/ijo.12.1.153