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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Jan 1998 Volume 12 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jan 1998 Volume 12 Issue 1

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Article

Comparison of telomerase activity in normal chorionic villi to trophoblastic diseases.

  • Authors:
    • H Nishi
    • N Yahata
    • K Ohyashiki
    • K Isaka
    • K Shiraishi
    • J H Ohyashiki
    • K Toyama
    • M Takayama
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Tokyo Medical College, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160, Japan.
  • Pages: 81-86
    |
    Published online on: January 1, 1998
       https://doi.org/10.3892/ijo.12.1.81
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Abstract

Trophoblasts are derived from the normal placenta, and they infiltrate into the endometrium and the maternal blood vessels under strict control but, unlike malignant cells, never metastasize. To understand the proliferative characteristics of trophoblasts and its related disorders, we assessed telomerase activity in chorionic villi obtained from 27 normal individuals, 9 hydatidiform moles, and 2 choriocarcinomas. Telomerase activity was detected in 13/27 (48%) normal chorionic villi samples. The detectability and the level of telomerase activity depended on gestational age; 8/10 (80%) villi samples in the first trimester (relative telomerase activity; 1.77 +/- 1.37), whereas 2/8 (25%) villi samples in the second trimester (0.78 +/- 1.52) and 3/9 (33%) in the third trimester (0.28 +/- 0.43) had telomerase activity. Telomerase activity of normal chorionic villi in the first trimester was higher than that of the third trimester (P = 0.0251). In contrast, all mole samples had increased telomerase activity compared to normal villi (3.17 +/- 2.81, P = 0.0152). Thus, a relationship may exist among cell proliferation, telomerase activity, and progression to trophoblastic disease.

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Copy and paste a formatted citation
Spandidos Publications style
Nishi H, Yahata N, Ohyashiki K, Isaka K, Shiraishi K, Ohyashiki J, Toyama K and Takayama M: Comparison of telomerase activity in normal chorionic villi to trophoblastic diseases.. Int J Oncol 12: 81-86, 1998.
APA
Nishi, H., Yahata, N., Ohyashiki, K., Isaka, K., Shiraishi, K., Ohyashiki, J. ... Takayama, M. (1998). Comparison of telomerase activity in normal chorionic villi to trophoblastic diseases.. International Journal of Oncology, 12, 81-86. https://doi.org/10.3892/ijo.12.1.81
MLA
Nishi, H., Yahata, N., Ohyashiki, K., Isaka, K., Shiraishi, K., Ohyashiki, J., Toyama, K., Takayama, M."Comparison of telomerase activity in normal chorionic villi to trophoblastic diseases.". International Journal of Oncology 12.1 (1998): 81-86.
Chicago
Nishi, H., Yahata, N., Ohyashiki, K., Isaka, K., Shiraishi, K., Ohyashiki, J., Toyama, K., Takayama, M."Comparison of telomerase activity in normal chorionic villi to trophoblastic diseases.". International Journal of Oncology 12, no. 1 (1998): 81-86. https://doi.org/10.3892/ijo.12.1.81
Copy and paste a formatted citation
x
Spandidos Publications style
Nishi H, Yahata N, Ohyashiki K, Isaka K, Shiraishi K, Ohyashiki J, Toyama K and Takayama M: Comparison of telomerase activity in normal chorionic villi to trophoblastic diseases.. Int J Oncol 12: 81-86, 1998.
APA
Nishi, H., Yahata, N., Ohyashiki, K., Isaka, K., Shiraishi, K., Ohyashiki, J. ... Takayama, M. (1998). Comparison of telomerase activity in normal chorionic villi to trophoblastic diseases.. International Journal of Oncology, 12, 81-86. https://doi.org/10.3892/ijo.12.1.81
MLA
Nishi, H., Yahata, N., Ohyashiki, K., Isaka, K., Shiraishi, K., Ohyashiki, J., Toyama, K., Takayama, M."Comparison of telomerase activity in normal chorionic villi to trophoblastic diseases.". International Journal of Oncology 12.1 (1998): 81-86.
Chicago
Nishi, H., Yahata, N., Ohyashiki, K., Isaka, K., Shiraishi, K., Ohyashiki, J., Toyama, K., Takayama, M."Comparison of telomerase activity in normal chorionic villi to trophoblastic diseases.". International Journal of Oncology 12, no. 1 (1998): 81-86. https://doi.org/10.3892/ijo.12.1.81
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