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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Mar 1998 Volume 12 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Mar 1998 Volume 12 Issue 3

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Article

Tumour therapy in mice using adenovirus vectors expressing human TNFa.

  • Authors:
    • R A Marr
    • M Hitt
    • W J Muller
    • J Gauldie
    • F L Graham

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.
  • Pages: 509-524
    |
    Published online on: March 1, 1998
       https://doi.org/10.3892/ijo.12.3.509
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Abstract

Induction of systemic toxicity is a major factor limiting the use of TNFa in tumour therapy. The local expression of TNFa from Ad vector infected tumour cells, might result in reduced systemic toxicity and induce an enhanced local antitumour response. Two adenoviral vectors expressing human TNFa were constructed for use in tumour immunotherapy, one utilizing the HCMV promoter (Ad-HCMV-TNF) and the second utilizing the MCMV promoter (Ad-MCMV-TNF). Both vectors induced the secretion of hTNFa from transduced cells in vitro, however the MCMV promoter directed stronger expression in murine cells. Expression from the two vectors was also kinetically different with the MCMV promoter inducing earlier expression, from murine tumour cells in vitro and in vivo. Both vectors induced intratumoural necrosis, however only the Ad-MCMV-TNF vector induced systemic toxicity and significant antitumour activity when directly injected into tumours, killing 8 of 20 mice and inducing partial (2 of 12) and permanent (1 of 12) tumour regressions at a dose of 5x108 pfu/mouse. These data indicate that hTNFa expressed from an Ad vector is considerably toxic to mice while inducing a moderate antitumour response.

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Copy and paste a formatted citation
Spandidos Publications style
Marr R, Hitt M, Muller W, Gauldie J and Graham F: Tumour therapy in mice using adenovirus vectors expressing human TNFa.. Int J Oncol 12: 509-524, 1998.
APA
Marr, R., Hitt, M., Muller, W., Gauldie, J., & Graham, F. (1998). Tumour therapy in mice using adenovirus vectors expressing human TNFa.. International Journal of Oncology, 12, 509-524. https://doi.org/10.3892/ijo.12.3.509
MLA
Marr, R., Hitt, M., Muller, W., Gauldie, J., Graham, F."Tumour therapy in mice using adenovirus vectors expressing human TNFa.". International Journal of Oncology 12.3 (1998): 509-524.
Chicago
Marr, R., Hitt, M., Muller, W., Gauldie, J., Graham, F."Tumour therapy in mice using adenovirus vectors expressing human TNFa.". International Journal of Oncology 12, no. 3 (1998): 509-524. https://doi.org/10.3892/ijo.12.3.509
Copy and paste a formatted citation
x
Spandidos Publications style
Marr R, Hitt M, Muller W, Gauldie J and Graham F: Tumour therapy in mice using adenovirus vectors expressing human TNFa.. Int J Oncol 12: 509-524, 1998.
APA
Marr, R., Hitt, M., Muller, W., Gauldie, J., & Graham, F. (1998). Tumour therapy in mice using adenovirus vectors expressing human TNFa.. International Journal of Oncology, 12, 509-524. https://doi.org/10.3892/ijo.12.3.509
MLA
Marr, R., Hitt, M., Muller, W., Gauldie, J., Graham, F."Tumour therapy in mice using adenovirus vectors expressing human TNFa.". International Journal of Oncology 12.3 (1998): 509-524.
Chicago
Marr, R., Hitt, M., Muller, W., Gauldie, J., Graham, F."Tumour therapy in mice using adenovirus vectors expressing human TNFa.". International Journal of Oncology 12, no. 3 (1998): 509-524. https://doi.org/10.3892/ijo.12.3.509
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