Expression of CD44 splicing isoforms in lung cancers: dominant expression of CD44v8-10 in non-small cell lung carcinomas.

  • Authors:
    • J I Sasaki
    • K K Tanabe
    • K Takahashi
    • I Okamoto
    • H Fujimoto
    • M Matsumoto
    • M Suga
    • M Ando
    • H Saya
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijo.12.3.525
  • Pages: 525-558
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Abstract

We examined CD44 isoform expression in 138 frozen tissue samples, which included primary lung carcinomas, adjacent non-tumorous lung tissues and benign lung diseases, by both reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemical analyses. CD44v8-10 mRNA and protein were dominantly expressed in non-small cell lung carcinomas (NSCLC), while non-tumorous tissues principally expressed CD44s and small cell lung carcinomas (SCLC) expressed either CD44s or no detectable CD44. These results indicate that CD44v8-10 is the dominant splicing isoform in NSCLC and can be practically utilized as a diagnostic marker and therapeutical target in NSCLC.

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Mar 1998
Volume 12 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Sasaki J, Tanabe K, Takahashi K, Okamoto I, Fujimoto H, Matsumoto M, Suga M, Ando M and Saya H: Expression of CD44 splicing isoforms in lung cancers: dominant expression of CD44v8-10 in non-small cell lung carcinomas.. Int J Oncol 12: 525-558, 1998
APA
Sasaki, J., Tanabe, K., Takahashi, K., Okamoto, I., Fujimoto, H., Matsumoto, M. ... Saya, H. (1998). Expression of CD44 splicing isoforms in lung cancers: dominant expression of CD44v8-10 in non-small cell lung carcinomas.. International Journal of Oncology, 12, 525-558. https://doi.org/10.3892/ijo.12.3.525
MLA
Sasaki, J., Tanabe, K., Takahashi, K., Okamoto, I., Fujimoto, H., Matsumoto, M., Suga, M., Ando, M., Saya, H."Expression of CD44 splicing isoforms in lung cancers: dominant expression of CD44v8-10 in non-small cell lung carcinomas.". International Journal of Oncology 12.3 (1998): 525-558.
Chicago
Sasaki, J., Tanabe, K., Takahashi, K., Okamoto, I., Fujimoto, H., Matsumoto, M., Suga, M., Ando, M., Saya, H."Expression of CD44 splicing isoforms in lung cancers: dominant expression of CD44v8-10 in non-small cell lung carcinomas.". International Journal of Oncology 12, no. 3 (1998): 525-558. https://doi.org/10.3892/ijo.12.3.525