Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.

  • Authors:
    • C L Huang
    • T Taki
    • M Adachi
    • T Konishi
    • M Higashiyama
    • M Kinoshita
    • T Hadama
    • M Miyake
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijo.12.3.553
  • Pages: 553-616
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Abstract

To evaluate the importance of mutations of p53 and K-ras genes in the prognosis of patients with non-small cell lung cancer, one hundred and forty-four patients who underwent surgery were studied. DNA was extracted from frozen specimens. Polymerase chain reaction-single strand conformation polymorphism and sequencing were performed to investigate mutations of p53 from exon 5 to 8, and mutations of exon 1 of K-ras. Mutations of p53 gene occurred in 35. 4% of patients, and mutations of the K-ras gene in 8.3%. The overall survival rate of non-small cell lung cancer patients with wild-type K-ras was better than that of patients whose tumors had mutations of K-ras (P=0.0330). Among patients with adenocarcinoma of the lung, the overall survival rate of patients with wild-type p53 was strikingly better than that of patients whose tumors had mutations of p53 (P=0.0234). Multivariate analysis with the Cox regression model of all patients with non-small cell lung cancer and those with adenocarcinoma indicated that mutations of K-ras best correlated with the overall survival rate (P=0.0005 and P=0.0361, respectively). In conclusion, evaluation of mutations of both the p53 and K-ras genes in the lung tumors might be useful for assessing the prognosis, especially in patients with adenocarcinoma.

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Mar 1998
Volume 12 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Huang C, Taki T, Adachi M, Konishi T, Higashiyama M, Kinoshita M, Hadama T and Miyake M: Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.. Int J Oncol 12: 553-616, 1998
APA
Huang, C., Taki, T., Adachi, M., Konishi, T., Higashiyama, M., Kinoshita, M. ... Miyake, M. (1998). Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.. International Journal of Oncology, 12, 553-616. https://doi.org/10.3892/ijo.12.3.553
MLA
Huang, C., Taki, T., Adachi, M., Konishi, T., Higashiyama, M., Kinoshita, M., Hadama, T., Miyake, M."Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.". International Journal of Oncology 12.3 (1998): 553-616.
Chicago
Huang, C., Taki, T., Adachi, M., Konishi, T., Higashiyama, M., Kinoshita, M., Hadama, T., Miyake, M."Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.". International Journal of Oncology 12, no. 3 (1998): 553-616. https://doi.org/10.3892/ijo.12.3.553