The role of proteolytic enzymes in the pathology of epithelial ovarian carcinoma.

  • Authors:
    • M S Stack
    • S M Ellerbroek
    • D A Fishman
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijo.12.3.569
  • Pages: 569-645
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Abstract

Epithelial ovarian cancer is the leading cause of death from gynecologic malignancy among North American women. The vast majority of women are diagnosed after the cancer has metastasized into the peritoneum, resulting in a low 5-year survival. Because of difficulties associated with early detection of ovarian carcinoma and the invasive potential of these malignancies, a more detailed understanding of the mechanism(s) by which ovarian carcinomas metastasize may suggest novel therapeutic approaches which could impact favorably on long-term survival. Connective tissue degrading proteinases are necessary for tumor cell invasion and enzymes in the plasminogen activator (PA) and matrix metalloproteinase (MMP) families have been implicated in ovarian cancer metastasis. The goal of this review is to summarize current data regarding the role of these proteinases in ovarian carcinoma invasion.

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Mar 1998
Volume 12 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Stack M, Ellerbroek S and Fishman D: The role of proteolytic enzymes in the pathology of epithelial ovarian carcinoma.. Int J Oncol 12: 569-645, 1998
APA
Stack, M., Ellerbroek, S., & Fishman, D. (1998). The role of proteolytic enzymes in the pathology of epithelial ovarian carcinoma.. International Journal of Oncology, 12, 569-645. https://doi.org/10.3892/ijo.12.3.569
MLA
Stack, M., Ellerbroek, S., Fishman, D."The role of proteolytic enzymes in the pathology of epithelial ovarian carcinoma.". International Journal of Oncology 12.3 (1998): 569-645.
Chicago
Stack, M., Ellerbroek, S., Fishman, D."The role of proteolytic enzymes in the pathology of epithelial ovarian carcinoma.". International Journal of Oncology 12, no. 3 (1998): 569-645. https://doi.org/10.3892/ijo.12.3.569