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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Apr 1998 Volume 12 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Apr 1998 Volume 12 Issue 4

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Article

Conversion of normal human oral keratinocytes to tumorigenic cells is associated with the acquisition of resistance to TGF-beta.

  • Authors:
    • K M Woo
    • G Lee
    • J K Kook
    • B M Min

  • View Affiliations / Copyright

    Affiliations: Department of Oral Biochemistry and Dental Research College of Dentistry, Kangnung National University, Kangnung, Korea.
  • Pages: 833-842
    |
    Published online on: April 1, 1998
       https://doi.org/10.3892/ijo.12.4.833
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Abstract

Normal human epithelial cells cannot proliferate and undergo apoptosis in the presence of transforming growth factor-beta (TGF-beta) in vitro, but many human epidermoid cancer cells are resistant to TGF-beta. Resistance to TGF-beta may thus, in part, be responsible for uncontrolled proliferation of cancer cells. Though detailed mechanisms for the resistance of cancer cells to TGF-beta remain unknown, resistance may be due to decreased expression of TGF-beta receptors from cancer cells. To investigate this possibility, we determined the expression of TGF-beta and type II TGF-beta receptor in primary normal human oral keratinocytes (NHOK), human papillomavirus-immortalized human oral keratinocytes (HOK-16B) and two tumor cell lines derived from HOK-16B (CTHOK-16B-BaP and CTHOK-16B-DMBA). Our results show that (1) the cellular and secretory TGF-beta levels in immortalized and tumor cells were notably lower than in NHOK and (2) the level of type II TGF-beta receptor of the tested cells was similar to each other. Taken together, the conversion of NHOK to tumorigenic cells may, in part, be due to the acquisition of NHOK resistance to TGF-beta through underexpression of this cytokine.

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Copy and paste a formatted citation
Spandidos Publications style
Woo K, Lee G, Kook J and Min B: Conversion of normal human oral keratinocytes to tumorigenic cells is associated with the acquisition of resistance to TGF-beta.. Int J Oncol 12: 833-842, 1998.
APA
Woo, K., Lee, G., Kook, J., & Min, B. (1998). Conversion of normal human oral keratinocytes to tumorigenic cells is associated with the acquisition of resistance to TGF-beta.. International Journal of Oncology, 12, 833-842. https://doi.org/10.3892/ijo.12.4.833
MLA
Woo, K., Lee, G., Kook, J., Min, B."Conversion of normal human oral keratinocytes to tumorigenic cells is associated with the acquisition of resistance to TGF-beta.". International Journal of Oncology 12.4 (1998): 833-842.
Chicago
Woo, K., Lee, G., Kook, J., Min, B."Conversion of normal human oral keratinocytes to tumorigenic cells is associated with the acquisition of resistance to TGF-beta.". International Journal of Oncology 12, no. 4 (1998): 833-842. https://doi.org/10.3892/ijo.12.4.833
Copy and paste a formatted citation
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Spandidos Publications style
Woo K, Lee G, Kook J and Min B: Conversion of normal human oral keratinocytes to tumorigenic cells is associated with the acquisition of resistance to TGF-beta.. Int J Oncol 12: 833-842, 1998.
APA
Woo, K., Lee, G., Kook, J., & Min, B. (1998). Conversion of normal human oral keratinocytes to tumorigenic cells is associated with the acquisition of resistance to TGF-beta.. International Journal of Oncology, 12, 833-842. https://doi.org/10.3892/ijo.12.4.833
MLA
Woo, K., Lee, G., Kook, J., Min, B."Conversion of normal human oral keratinocytes to tumorigenic cells is associated with the acquisition of resistance to TGF-beta.". International Journal of Oncology 12.4 (1998): 833-842.
Chicago
Woo, K., Lee, G., Kook, J., Min, B."Conversion of normal human oral keratinocytes to tumorigenic cells is associated with the acquisition of resistance to TGF-beta.". International Journal of Oncology 12, no. 4 (1998): 833-842. https://doi.org/10.3892/ijo.12.4.833
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