Genetic identification and management of hereditary nonpolyposis colorectal cancer.

  • Authors:
    • J G Park
    • Y Yuan
  • View Affiliations

  • Published online on: April 1, 1998     https://doi.org/10.3892/ijo.12.4.947
  • Pages: 947-1002
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Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is a syndrome involving a predisposition to cancers of the colon, endometrium and several other extra-colonic sites, accounting for approximately 1-5% of all colorectal cancer cases. It is not easily recognized because of a lack of distinctive clinical markers, making diagnosis and management of this disease problematic. To provide a basis for uniformity in diagnosis of HNPCC, the Amsterdam criteria were proposed and are currently in use. More recently, the discovery of four human mismatch repair genes (hMSH2, hMLH1, hPMS1 and hPMS2) has provided novel insight into the genetic basis of this disease, and raised the possibility of genetic diagnosis for management of HNPCC patients and their family members. This report summarizes the clinicopathologic aspects of HNPCC, reviews the recent genetic findings and surveillance strategies, and suggests a novel designation of certain patients as suspected HNPCC.

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Apr 1998
Volume 12 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Park J and Yuan Y: Genetic identification and management of hereditary nonpolyposis colorectal cancer.. Int J Oncol 12: 947-1002, 1998.
APA
Park, J., & Yuan, Y. (1998). Genetic identification and management of hereditary nonpolyposis colorectal cancer.. International Journal of Oncology, 12, 947-1002. https://doi.org/10.3892/ijo.12.4.947
MLA
Park, J., Yuan, Y."Genetic identification and management of hereditary nonpolyposis colorectal cancer.". International Journal of Oncology 12.4 (1998): 947-1002.
Chicago
Park, J., Yuan, Y."Genetic identification and management of hereditary nonpolyposis colorectal cancer.". International Journal of Oncology 12, no. 4 (1998): 947-1002. https://doi.org/10.3892/ijo.12.4.947