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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Apr 1998 Volume 12 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Apr 1998 Volume 12 Issue 4

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Article

Genetic identification and management of hereditary nonpolyposis colorectal cancer.

  • Authors:
    • J G Park
    • Y Yuan
  • View Affiliations / Copyright

    Affiliations: Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, 28, Yongon-dong, Chongno-gu, Seoul, 110-744, Korea.
  • Pages: 947-1002
    |
    Published online on: April 1, 1998
       https://doi.org/10.3892/ijo.12.4.947
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Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is a syndrome involving a predisposition to cancers of the colon, endometrium and several other extra-colonic sites, accounting for approximately 1-5% of all colorectal cancer cases. It is not easily recognized because of a lack of distinctive clinical markers, making diagnosis and management of this disease problematic. To provide a basis for uniformity in diagnosis of HNPCC, the Amsterdam criteria were proposed and are currently in use. More recently, the discovery of four human mismatch repair genes (hMSH2, hMLH1, hPMS1 and hPMS2) has provided novel insight into the genetic basis of this disease, and raised the possibility of genetic diagnosis for management of HNPCC patients and their family members. This report summarizes the clinicopathologic aspects of HNPCC, reviews the recent genetic findings and surveillance strategies, and suggests a novel designation of certain patients as suspected HNPCC.

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Copy and paste a formatted citation
Spandidos Publications style
Park J and Yuan Y: Genetic identification and management of hereditary nonpolyposis colorectal cancer.. Int J Oncol 12: 947-1002, 1998.
APA
Park, J., & Yuan, Y. (1998). Genetic identification and management of hereditary nonpolyposis colorectal cancer.. International Journal of Oncology, 12, 947-1002. https://doi.org/10.3892/ijo.12.4.947
MLA
Park, J., Yuan, Y."Genetic identification and management of hereditary nonpolyposis colorectal cancer.". International Journal of Oncology 12.4 (1998): 947-1002.
Chicago
Park, J., Yuan, Y."Genetic identification and management of hereditary nonpolyposis colorectal cancer.". International Journal of Oncology 12, no. 4 (1998): 947-1002. https://doi.org/10.3892/ijo.12.4.947
Copy and paste a formatted citation
x
Spandidos Publications style
Park J and Yuan Y: Genetic identification and management of hereditary nonpolyposis colorectal cancer.. Int J Oncol 12: 947-1002, 1998.
APA
Park, J., & Yuan, Y. (1998). Genetic identification and management of hereditary nonpolyposis colorectal cancer.. International Journal of Oncology, 12, 947-1002. https://doi.org/10.3892/ijo.12.4.947
MLA
Park, J., Yuan, Y."Genetic identification and management of hereditary nonpolyposis colorectal cancer.". International Journal of Oncology 12.4 (1998): 947-1002.
Chicago
Park, J., Yuan, Y."Genetic identification and management of hereditary nonpolyposis colorectal cancer.". International Journal of Oncology 12, no. 4 (1998): 947-1002. https://doi.org/10.3892/ijo.12.4.947
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