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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 1998 Volume 12 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1998 Volume 12 Issue 5

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Article

Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.

  • Authors:
    • H Yoshida
    • H Enomoto
    • M Miyauchi
    • K Takenaga
    • M Tanabe
    • N Ohnuma
    • S Sakiyama
    • M Tagawa

  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, Chiba University, School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
  • Pages: 1067-1138
    |
    Published online on: May 1, 1998
       https://doi.org/10.3892/ijo.12.5.1067
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Abstract

We have examined antitumor effect of murine neuroblastoma cells (C1300) retrovirally transduced with interleukin-4 (IL-4) gene in syngeneic A/J and nude mice. Although in vitro proliferation of IL-4-secreting C1300 cells (C1300/IL-4) was not different from that of wild-type cells, the in vivo tumor growth of C1300/IL-4 cells subcutaneously inoculated into immunocompetent A/J mice was retarded compared with that of wild-type cells and consequently, the survival of the A/J mice which received C1300/IL-4 cells was prolonged. In immunodeficient nude mice we observed accelerated growth rate of wild-type tumors in comparison with the tumors developed in A/J mice. In contrast, the tumor growth of C1300/IL-4 cells in nude mice was significantly suppressed and the growth was much slower than that of C1300/IL-4 cells inoculated in A/J mice. Thus, the secretion of IL-4 from tumor cells produced antitumor effect more efficiently in mature T cell-defective hosts than in immunocompetent mice. Our results suggest a possible clinical application of IL-4 expression in tumor cells via genetic manipulations especially in immunocompromised cancer patients.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshida H, Enomoto H, Miyauchi M, Takenaga K, Tanabe M, Ohnuma N, Sakiyama S and Tagawa M: Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.. Int J Oncol 12: 1067-1138, 1998.
APA
Yoshida, H., Enomoto, H., Miyauchi, M., Takenaga, K., Tanabe, M., Ohnuma, N. ... Tagawa, M. (1998). Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.. International Journal of Oncology, 12, 1067-1138. https://doi.org/10.3892/ijo.12.5.1067
MLA
Yoshida, H., Enomoto, H., Miyauchi, M., Takenaga, K., Tanabe, M., Ohnuma, N., Sakiyama, S., Tagawa, M."Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.". International Journal of Oncology 12.5 (1998): 1067-1138.
Chicago
Yoshida, H., Enomoto, H., Miyauchi, M., Takenaga, K., Tanabe, M., Ohnuma, N., Sakiyama, S., Tagawa, M."Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.". International Journal of Oncology 12, no. 5 (1998): 1067-1138. https://doi.org/10.3892/ijo.12.5.1067
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshida H, Enomoto H, Miyauchi M, Takenaga K, Tanabe M, Ohnuma N, Sakiyama S and Tagawa M: Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.. Int J Oncol 12: 1067-1138, 1998.
APA
Yoshida, H., Enomoto, H., Miyauchi, M., Takenaga, K., Tanabe, M., Ohnuma, N. ... Tagawa, M. (1998). Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.. International Journal of Oncology, 12, 1067-1138. https://doi.org/10.3892/ijo.12.5.1067
MLA
Yoshida, H., Enomoto, H., Miyauchi, M., Takenaga, K., Tanabe, M., Ohnuma, N., Sakiyama, S., Tagawa, M."Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.". International Journal of Oncology 12.5 (1998): 1067-1138.
Chicago
Yoshida, H., Enomoto, H., Miyauchi, M., Takenaga, K., Tanabe, M., Ohnuma, N., Sakiyama, S., Tagawa, M."Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.". International Journal of Oncology 12, no. 5 (1998): 1067-1138. https://doi.org/10.3892/ijo.12.5.1067
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