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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 1998 Volume 12 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1998 Volume 12 Issue 5

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Article

Characterization, cloning and expression of the Tage4 gene, a member of the immunoglobulin superfamily.

  • Authors:
    • M G Denis

  • View Affiliations / Copyright

    Affiliations: Laboratoire de Biochimie Specialisee, Institut de Biologie, 9 quai Moncousu, Nantes, 44035, France.
  • Pages: 997-2002
    |
    Published online on: May 1, 1998
       https://doi.org/10.3892/ijo.12.5.997
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Abstract

pE4 is a rat carcinoma-associated antigen identified by monoclonal antibody E4, which was raised against a rat colon carcinoma cell line. This glycoprotein is expressed at the surface of all the rat colon carcinoma cell lines tested, as determined by immunofluorescence analysis. In contrast, a barely detectable level was found on normal adult rat colon and lung and no expression could be detected on the other normal rat tissues tested. The corresponding Tage4 gene (tumor-associated glycoprotein E4) is also expressed in rat colon tumors induced by 1,2-dimethylhydrazine and in Min mouse intestinal adenomas. The Tage4 gene product is closely related to the hepatocellular carcinoma antigen TuAg.1. The Tage4 cDNA has been isolated and sequenced. Analysis of the deduced aminoacid sequence indicated that Tage4 is a member of the immunoglobulin supergene family. This family contains cell adhesion molecules which have wide-ranging functions and mediate a variety of homotypic and heterotypic cellular interactions playing a general role in cell surface recognition. The Tage4 gene has been mapped to rat chromosome 1q22 and mouse 7A2-B1, regions that are homologous to the long arm of human chromosome 19. Summary review of our work is presented.

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Copy and paste a formatted citation
Spandidos Publications style
Denis M: Characterization, cloning and expression of the Tage4 gene, a member of the immunoglobulin superfamily.. Int J Oncol 12: 997-2002, 1998.
APA
Denis, M. (1998). Characterization, cloning and expression of the Tage4 gene, a member of the immunoglobulin superfamily.. International Journal of Oncology, 12, 997-2002. https://doi.org/10.3892/ijo.12.5.997
MLA
Denis, M."Characterization, cloning and expression of the Tage4 gene, a member of the immunoglobulin superfamily.". International Journal of Oncology 12.5 (1998): 997-2002.
Chicago
Denis, M."Characterization, cloning and expression of the Tage4 gene, a member of the immunoglobulin superfamily.". International Journal of Oncology 12, no. 5 (1998): 997-2002. https://doi.org/10.3892/ijo.12.5.997
Copy and paste a formatted citation
x
Spandidos Publications style
Denis M: Characterization, cloning and expression of the Tage4 gene, a member of the immunoglobulin superfamily.. Int J Oncol 12: 997-2002, 1998.
APA
Denis, M. (1998). Characterization, cloning and expression of the Tage4 gene, a member of the immunoglobulin superfamily.. International Journal of Oncology, 12, 997-2002. https://doi.org/10.3892/ijo.12.5.997
MLA
Denis, M."Characterization, cloning and expression of the Tage4 gene, a member of the immunoglobulin superfamily.". International Journal of Oncology 12.5 (1998): 997-2002.
Chicago
Denis, M."Characterization, cloning and expression of the Tage4 gene, a member of the immunoglobulin superfamily.". International Journal of Oncology 12, no. 5 (1998): 997-2002. https://doi.org/10.3892/ijo.12.5.997
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