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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Jul 1998 Volume 13 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
Jul 1998 Volume 13 Issue 1

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Article

Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.

  • Authors:
    • A Yokomizo
    • D J Tindall
    • L Hartmann
    • R B Jenkins
    • D I Smith
    • W Liu

  • View Affiliations / Copyright

    Affiliations: Division of Experimental Pathology, Department of Laboratory Medicine and Pathology and Department of Urology Research, Mayo Clinic/Foundation, Rochester, MN 55905, USA.
  • Pages: 101-106
    |
    Published online on: July 1, 1998
       https://doi.org/10.3892/ijo.13.1.101
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Abstract

A putative tumor suppressor, PTEN/MMAC1 gene was recently identified at 10q23 and was found to be frequently altered in several types of human tumors. To determine the possible role of this gene in human ovarian tumors, we screened 31 unselected primary epithelial ovarian cancers with matched normal tissues and 7 ovarian cancer cell lines. Two homozygous deletions (4.8%) were detected in primary ovarian tumors by a semi-quantitative multiplex polymerase chain reaction. However, no point mutations were observed in any of the PTEN/MMAC1 coding sequences as determined by denaturing high-performance liquid chromatography and DNA sequencing. These data indicate that PTEN/MMAC1 mutations are rare in ovarian cancers.

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Copy and paste a formatted citation
Spandidos Publications style
Yokomizo A, Tindall D, Hartmann L, Jenkins R, Smith D and Liu W: Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.. Int J Oncol 13: 101-106, 1998.
APA
Yokomizo, A., Tindall, D., Hartmann, L., Jenkins, R., Smith, D., & Liu, W. (1998). Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.. International Journal of Oncology, 13, 101-106. https://doi.org/10.3892/ijo.13.1.101
MLA
Yokomizo, A., Tindall, D., Hartmann, L., Jenkins, R., Smith, D., Liu, W."Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.". International Journal of Oncology 13.1 (1998): 101-106.
Chicago
Yokomizo, A., Tindall, D., Hartmann, L., Jenkins, R., Smith, D., Liu, W."Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.". International Journal of Oncology 13, no. 1 (1998): 101-106. https://doi.org/10.3892/ijo.13.1.101
Copy and paste a formatted citation
x
Spandidos Publications style
Yokomizo A, Tindall D, Hartmann L, Jenkins R, Smith D and Liu W: Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.. Int J Oncol 13: 101-106, 1998.
APA
Yokomizo, A., Tindall, D., Hartmann, L., Jenkins, R., Smith, D., & Liu, W. (1998). Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.. International Journal of Oncology, 13, 101-106. https://doi.org/10.3892/ijo.13.1.101
MLA
Yokomizo, A., Tindall, D., Hartmann, L., Jenkins, R., Smith, D., Liu, W."Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.". International Journal of Oncology 13.1 (1998): 101-106.
Chicago
Yokomizo, A., Tindall, D., Hartmann, L., Jenkins, R., Smith, D., Liu, W."Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer.". International Journal of Oncology 13, no. 1 (1998): 101-106. https://doi.org/10.3892/ijo.13.1.101
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