Genetic and epigenetic influences in prostatic carcinogenesis (review).

  • Authors:
    • S W Hayward
    • G D Grossfeld
    • T D Tlsty
    • G R Cunha
  • View Affiliations

  • Published online on: July 1, 1998     https://doi.org/10.3892/ijo.13.1.35
  • Pages: 35-82
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Abstract

Prostatic carcinogenesis is a multistep process with well-documented stages. Although prostate cancer is a major cause of mortality many small tumor foci never progress to form clinically significant disease, indicating that the disease process may be regulated at more than one level. Carcinogenesis is accompanied by increasing genetic damage to prostatic epithelial cells, however the pattern of genetic lesions is inconsistent. The differentiation of stromal cells surrounding tumors is more fibroblastic and less muscular than in normal prostate. The present communication reviews the roles of both genetic and, stromally derived, epigenetic effects on prostatic tumorigenesis.

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Jul 1998
Volume 13 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Hayward S, Grossfeld G, Tlsty T and Cunha G: Genetic and epigenetic influences in prostatic carcinogenesis (review).. Int J Oncol 13: 35-82, 1998
APA
Hayward, S., Grossfeld, G., Tlsty, T., & Cunha, G. (1998). Genetic and epigenetic influences in prostatic carcinogenesis (review).. International Journal of Oncology, 13, 35-82. https://doi.org/10.3892/ijo.13.1.35
MLA
Hayward, S., Grossfeld, G., Tlsty, T., Cunha, G."Genetic and epigenetic influences in prostatic carcinogenesis (review).". International Journal of Oncology 13.1 (1998): 35-82.
Chicago
Hayward, S., Grossfeld, G., Tlsty, T., Cunha, G."Genetic and epigenetic influences in prostatic carcinogenesis (review).". International Journal of Oncology 13, no. 1 (1998): 35-82. https://doi.org/10.3892/ijo.13.1.35