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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Aug 1998 Volume 13 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Aug 1998 Volume 13 Issue 2

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Article

The apoptotic effects of cisplatin and carboplatin in retinoblastoma Y79 cells.

  • Authors:
    • V Di Felice
    • M Lauricella
    • M Giuliano
    • S Emanuele
    • R Vento
    • G Tesoriere
  • View Affiliations / Copyright

    Affiliations: Institute of Biological Chemistry, University of Palermo, Palermo, Italy.
  • Pages: 225-257
    |
    Published online on: August 1, 1998
       https://doi.org/10.3892/ijo.13.2.225
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Abstract

This study demonstrated that cisplatin and carboplatin stimulate apoptosis in human retinoblastoma Y79 cells, cisplatin being the most effective compound. The apoptotic effect appeared after 8 h and then increased in a time-dependent manner. Treatment with cisplatin and carboplatin also provoked an increase in the level of p53 and p21, and a lowering in Bcl-2. The prolonged exposure of Y79 cells to cisplatin induced resistance to cisplatin, carboplatin and etoposide. The basal level of p53 was in resistant cells higher than in untreated cells, while Bcl-2 was not modified. p53 and Bcl-2 levels did not change after treating of resistant cells with cisplatin, carboplatin or etoposide. However, camptothecin which is a powerful inducer of apoptosis in sensitive cells, triggered cell death even in resistant cells. Such an effect was not accompanied by any modification in p53 level while Bcl-2 was markedly reduced.

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Copy and paste a formatted citation
Spandidos Publications style
Di Felice V, Lauricella M, Giuliano M, Emanuele S, Vento R and Tesoriere G: The apoptotic effects of cisplatin and carboplatin in retinoblastoma Y79 cells.. Int J Oncol 13: 225-257, 1998.
APA
Di Felice, V., Lauricella, M., Giuliano, M., Emanuele, S., Vento, R., & Tesoriere, G. (1998). The apoptotic effects of cisplatin and carboplatin in retinoblastoma Y79 cells.. International Journal of Oncology, 13, 225-257. https://doi.org/10.3892/ijo.13.2.225
MLA
Di Felice, V., Lauricella, M., Giuliano, M., Emanuele, S., Vento, R., Tesoriere, G."The apoptotic effects of cisplatin and carboplatin in retinoblastoma Y79 cells.". International Journal of Oncology 13.2 (1998): 225-257.
Chicago
Di Felice, V., Lauricella, M., Giuliano, M., Emanuele, S., Vento, R., Tesoriere, G."The apoptotic effects of cisplatin and carboplatin in retinoblastoma Y79 cells.". International Journal of Oncology 13, no. 2 (1998): 225-257. https://doi.org/10.3892/ijo.13.2.225
Copy and paste a formatted citation
x
Spandidos Publications style
Di Felice V, Lauricella M, Giuliano M, Emanuele S, Vento R and Tesoriere G: The apoptotic effects of cisplatin and carboplatin in retinoblastoma Y79 cells.. Int J Oncol 13: 225-257, 1998.
APA
Di Felice, V., Lauricella, M., Giuliano, M., Emanuele, S., Vento, R., & Tesoriere, G. (1998). The apoptotic effects of cisplatin and carboplatin in retinoblastoma Y79 cells.. International Journal of Oncology, 13, 225-257. https://doi.org/10.3892/ijo.13.2.225
MLA
Di Felice, V., Lauricella, M., Giuliano, M., Emanuele, S., Vento, R., Tesoriere, G."The apoptotic effects of cisplatin and carboplatin in retinoblastoma Y79 cells.". International Journal of Oncology 13.2 (1998): 225-257.
Chicago
Di Felice, V., Lauricella, M., Giuliano, M., Emanuele, S., Vento, R., Tesoriere, G."The apoptotic effects of cisplatin and carboplatin in retinoblastoma Y79 cells.". International Journal of Oncology 13, no. 2 (1998): 225-257. https://doi.org/10.3892/ijo.13.2.225
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